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Plant production of high affinity nanobodies that block SARS-CoV-2 spike protein binding with its receptor, human angiotensin converting enzyme

Nanobodies(®) (V(HH) antibodies), are small peptides that represent the antigen binding domain, V(HH) of unique single domain antibodies (heavy chain only antibodies, HcAb) derived from camelids. Here, we demonstrate production of V(HH) nanobodies against the SARS-CoV-2 spike proteins in the solanac...

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Detalles Bibliográficos
Autores principales: Pitino, Marco, Fleites, Laura A., Shrum, Lauren, Heck, Michelle, Shatters, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822723/
https://www.ncbi.nlm.nih.gov/pubmed/36619377
http://dx.doi.org/10.3389/fbioe.2022.1045337