The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH(3)COO)Cl(2)(NH(3))(2)(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

The biological behavior of the axially unsymmetric antitumor prodrug (OC-6-44)-acetatodiamminedichloridohydroxidoplatinum(IV), 2, was deeply investigated and compared with that of analogous symmetric Pt(IV) complexes, namely, dihydroxido 1 and diacetato 3, which have a similar structure. The complex...

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Detalles Bibliográficos
Autores principales: Gabano, Elisabetta, Zanellato, Ilaria, Pinton, Giulia, Moro, Laura, Ravera, Mauro, Osella, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822769/
https://www.ncbi.nlm.nih.gov/pubmed/36620349
http://dx.doi.org/10.1155/2022/3698391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822769/
https://www.ncbi.nlm.nih.gov/pubmed/36620349
http://dx.doi.org/10.1155/2022/3698391

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