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Hcp1-loaded staphylococcal membrane vesicle vaccine protects against acute melioidosis
Burkholderia pseudomallei is the causal agent of melioidosis, a deadly tropical infectious disease that lacks a vaccine. On the basis of the attenuated Staphylococcus aureus RN4220-Δagr (RN), we engineered the RN4220-Δagr/pdhB-hcp1 strain (RN-Hcp1) to generate B. pseudomallei hemolysin-coregulated p...
Autores principales: | Zhu, Keting, Li, Gang, Li, Jia, Zheng, Mingxia, Peng, Xiaohui, Rao, Yifan, Li, Ming, Zhou, Renjie, Rao, Xiancai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822774/ https://www.ncbi.nlm.nih.gov/pubmed/36618368 http://dx.doi.org/10.3389/fimmu.2022.1089225 |
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