Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations

Random mutagenesis is the natural opportunity for proteins to evolve and biotechnologically it has been exploited to create diversity and identify variants with improved characteristics in the mutant pools. Rational mutagenesis based on biophysical assumptions and supported by computational power ha...

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Detalles Bibliográficos
Autores principales: Bai, Zixuan, Wang, Jiewen, Li, Jiaqi, Yuan, Haibin, Wang, Ping, Zhang, Miao, Feng, Yuanhang, Cao, Xiangtong, Cao, Xiangan, Kang, Guangbo, de Marco, Ario, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822835/
https://www.ncbi.nlm.nih.gov/pubmed/36659922
http://dx.doi.org/10.1016/j.csbj.2022.12.021

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