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Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model

Pleiotropic mechanisms have been implicated in Alzheimer’s disease (AD), including transcriptional dysregulation, protein misprocessing and synaptic dysfunction, but how they are mechanistically linked to induce cognitive deficits in AD is unclear. Here we find that the histone methyltransferase Smy...

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Detalles Bibliográficos
Autores principales:	Williams, Jamal B., Cao, Qing, Wang, Wei, Lee, Young-Ho, Qin, Luye, Zhong, Ping, Ren, Yong, Ma, Kaijie, Yan, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822922/ https://www.ncbi.nlm.nih.gov/pubmed/36609445 http://dx.doi.org/10.1038/s41467-022-35749-6

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