Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer’s disease brain. The role and targets of lncRNA GAS5 in the aging brain were elucidated using a GAS5-targeting small molecule NPC86...

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Detalles Bibliográficos
Autores principales: Patel, Rekha S., Lui, Ashley, Hudson, Charles, Moss, Lauren, Sparks, Robert P., Hill, Shannon E., Shi, Yan, Cai, Jianfeng, Blair, Laura J., Bickford, Paula C., Patel, Niketa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822944/
https://www.ncbi.nlm.nih.gov/pubmed/36609440
http://dx.doi.org/10.1038/s41598-022-27126-6

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