Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation

DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant DNA methylation is the most common molecular lesion in cancer cells. However, medical intervention has been limited to the use of broadly acting, small molecule-based demethylating drugs with significant si...

Descripción completa

Detalles Bibliográficos
Autores principales: Esposito, Carla L., Autiero, Ida, Sandomenico, Annamaria, Li, H., Bassal, Mahmoud A., Ibba, Maria L., Wang, Dongfang, Rinaldi, Lucrezia, Ummarino, Simone, Gaggi, Giulia, Borchiellini, Marta, Swiderski, Piotr, Ruvo, Menotti, Catuogno, Silvia, Ebralidze, Alexander K., Kortylewski, Marcin, de Franciscis, Vittorio, Di Ruscio, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823104/
https://www.ncbi.nlm.nih.gov/pubmed/36609400
http://dx.doi.org/10.1038/s41467-022-35222-4

Ejemplares similares

Ejemplares similares