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The AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens

Antiestrogens (AEs) are used to treat all stages of estrogen receptor (ER)-positive breast cancer. Selective estrogen receptor modulators such as tamoxifen have tissue-specific partial agonist activity, while selective estrogen receptor downregulators such as fulvestrant (ICI182,780) display a more...

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Detalles Bibliográficos
Autores principales:	Vallet, Amandine, El Ezzy, Mohamed, Diennet, Marine, Haidar, Salwa, Bouvier, Michel, Mader, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823126/ https://www.ncbi.nlm.nih.gov/pubmed/36460099 http://dx.doi.org/10.1016/j.jbc.2022.102757

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