Cargando…

The AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens

Antiestrogens (AEs) are used to treat all stages of estrogen receptor (ER)-positive breast cancer. Selective estrogen receptor modulators such as tamoxifen have tissue-specific partial agonist activity, while selective estrogen receptor downregulators such as fulvestrant (ICI182,780) display a more...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vallet, Amandine, El Ezzy, Mohamed, Diennet, Marine, Haidar, Salwa, Bouvier, Michel, Mader, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823126/ https://www.ncbi.nlm.nih.gov/pubmed/36460099 http://dx.doi.org/10.1016/j.jbc.2022.102757

Ejemplares similares

OR11-02 Structural Determinants of Pure Antiestrogenic Activity
por: Vallet, Amandine, et al.
Publicado: (2023)

Antiestrogens: structure-activity relationships and use in breast cancer treatment
por: Traboulsi, T, et al.
Publicado: (2016)

Estrogenic or antiestrogenic therapies for multiple myeloma?
por: Sola, Brigitte, et al.
Publicado: (2007)

SUN-011 Identification Of Regulators Of Estrogenic Signalling In ER-positive Breast Cancer Cells By Whole Genome shRNA Screening
por: Kulpa, Justyna, et al.
Publicado: (2019)

Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells
por: Traboulsi, Tatiana, et al.
Publicado: (2018)

Estrogen Receptor-Alpha 36 Mediates Mitogenic Antiestrogen Signaling in ER-Negative Breast Cancer Cells
por: Zhang, XinTian, et al.
Publicado: (2012)

Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand
por: El-Halawany, Ali M., et al.
Publicado: (2011)

Estrogenic/antiestrogenic activity of selected selective serotonin reuptake inhibitors
por: POP, ANCA, et al.
Publicado: (2015)

Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity
por: Fanning, S. W., et al.
Publicado: (2018)

Response of Estrogen Receptor-Positive Breast Cancer Tumorspheres to Antiestrogen Treatments
por: Ao, Ada, et al.
Publicado: (2011)

Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells
por: Pulliam, Nicholas, et al.
Publicado: (2019)

A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses
por: Clusan, Léa, et al.
Publicado: (2021)

Rosetta Stone for Cancer Cure: Comparison of the Anticancer Capacity of Endogenous Estrogens, Synthetic Estrogens and Antiestrogens
por: Suba, Zsuzsanna
Publicado: (2023)

Sumoylation of TCF21 downregulates the transcriptional activity of estrogen receptor-alpha
por: Ao, Xiang, et al.
Publicado: (2016)

The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules
por: Oliveira, Cleida A, et al.
Publicado: (2003)

Molecular conformation, receptor binding, and hormone action of natural and synthetic estrogens and antiestrogens.
por: Duax, W L, et al.
Publicado: (1985)

Dietary Estrogens Act through Estrogen Receptor-Mediated Processes and Show No Antiestrogenicity in Cultured Breast Cancer Cells.
por: Makela, S, et al.
Publicado: (1994)

Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen
por: Garcia-Reyero, Natàlia, et al.
Publicado: (2009)

Estrogenic, Antiestrogenic and Antiproliferative Activities of Euphorbia bicolor (Euphorbiaceae) Latex Extracts and Its Phytochemicals
por: Basu, Paramita, et al.
Publicado: (2019)

Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response
por: Silveira, Maruhen AD, et al.
Publicado: (2021)

The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance
por: Suba, Zsuzsanna
Publicado: (2015)

Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis
por: Porras, Lucas, et al.
Publicado: (2021)

Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis
por: Camargo, Mariana S, et al.
Publicado: (2013)

ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer
por: Kalyuga, Maria, et al.
Publicado: (2012)

Api5 a new cofactor of estrogen receptor alpha involved in breast cancer outcome
por: Basset, Céline, et al.
Publicado: (2017)

Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines
por: Journe, Fabrice, et al.
Publicado: (2006)

Effects of estrogens and antiestrogens on gonadal sex differentiation and embryonic development in the domestic fowl (Gallus gallus domesticus)
por: Jessl, Luzie, et al.
Publicado: (2018)

Compensatory Estrogen Signal Is Capable of DNA Repair in Antiestrogen-Responsive Cancer Cells via Activating Mutations
por: Suba, Zsuzsanna
Publicado: (2020)

The Antiestrogens Tamoxifen and Fulvestrant Abolish Estrogenic Impacts of 17α-ethinylestradiol on Male Calling Behavior of Xenopus laevis
por: Hoffmann, Frauke, et al.
Publicado: (2012)

Morphological Evidence for a Subpopulation Selection Effect by Estrogen and Antiestrogen Treatments in the Heterogeneous MCF-7 Cell Line
por: Palmari, Jacqueline, et al.
Publicado: (2000)

Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic approach
por: Santos-Martínez, Nancy, et al.
Publicado: (2014)

Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI
por: Mao, Chengjian, et al.
Publicado: (2016)

AlphaFill: enriching AlphaFold models with ligands and cofactors
por: Hekkelman, Maarten L., et al.
Publicado: (2022)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure
por: Arao, Yukitomo, et al.
Publicado: (2018)

Prenylation inhibitors stimulate both estrogen receptor α transcriptional activity through AF-1 and AF-2 and estrogen receptor β transcriptional activity
por: Cestac, Philippe, et al.
Publicado: (2005)

Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication
por: Zheng, Yingfeng, et al.
Publicado: (2019)

Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance
por: Li, Shibai, et al.
Publicado: (2021)

Influence of the Length and Positioning of the Antiestrogenic Side Chain of Endoxifen and 4-Hydroxytamoxifen on Gene Activation and Growth of Estrogen Receptor Positive Cancer Cells
por: Maximov, Philipp Y., et al.
Publicado: (2014)

Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs
por: Semina, Svetlana E., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hgctu3covaalr7ie4o257c20vm