Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth

Epidermal growth factor receptor (EGFR) signaling is frequently dysregulated in various cancers. The ubiquitin ligase Casitas B-lineage lymphoma proto-oncogene (Cbl) regulates degradation of activated EGFR through ubiquitination and acts as an adaptor to recruit proteins required for trafficking. He...

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Detalles Bibliográficos
Autores principales: Wisniewski, David J., Liyasova, Mariya S., Korrapati, Soumya, Zhang, Xu, Ratnayake, Shashikala, Chen, Qingrong, Gilbert, Samuel F., Catalano, Alexis, Voeller, Donna, Meerzaman, Daoud, Guha, Udayan, Porat-Shliom, Natalie, Annunziata, Christina M., Lipkowitz, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823131/
https://www.ncbi.nlm.nih.gov/pubmed/36470425
http://dx.doi.org/10.1016/j.jbc.2022.102766

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