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Nuclear factor Nrf2 promotes glycosidase OGG1 expression by activating the AKT pathway to enhance leukemia cell resistance to cytarabine

Chemotherapy resistance is the dominant challenge in the treatment of acute myeloid leukemia (AML). Nuclear factor E2–related factor 2 (Nrf2) exerts a vital function in drug resistance of many tumors. Nevertheless, the potential molecular mechanism of Nrf2 regulating the base excision repair pathway...

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Detalles Bibliográficos
Autores principales:	Shang, Qin, Pan, Chengyun, Zhang, Xi, Yang, Tonghua, Hu, Tianzhen, Zheng, Lin, Cao, Shuyun, Feng, Cheng, Hu, Xiuying, Chai, Xiao, Wang, Jishi, Fang, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823221/ https://www.ncbi.nlm.nih.gov/pubmed/36528059 http://dx.doi.org/10.1016/j.jbc.2022.102798

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