Leucine 434 is essential for docosahexaenoic acid–induced augmentation of L-glutamate transporter current

Astrocytic excitatory amino acid transporter 2 (EAAT2) plays a major role in removing the excitatory neurotransmitter L-glutamate (L-Glu) from synaptic clefts in the forebrain to prevent excitotoxicity. Polyunsaturated fatty acids such as docosahexaenoic acid (DHA, 22:6 n-3) enhance synaptic transmi...

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Detalles Bibliográficos
Autores principales: Takahashi, Kanako, Chen, Luying, Sayama, Misa, Wu, Mian, Hayashi, Mariko Kato, Irie, Tomohiko, Ohwada, Tomohiko, Sato, Kaoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823230/
https://www.ncbi.nlm.nih.gov/pubmed/36509140
http://dx.doi.org/10.1016/j.jbc.2022.102793

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