Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

Background: Pleiotropic actions of insulin and insulin-like growth factor I (IGF-I) in the brain are context- and cell-dependent, but whether this holds for their receptors (insulin receptor (IR) and IGF-I receptor (IGF-IR), respectively), is less clear. Methods: We compared mice lacking IR or IGF-I...

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Detalles Bibliográficos
Autores principales: Zegarra-Valdivia, Jonathan, Fernandez, Ana M., Martinez-Rachadell, Laura, Herrero-Labrador, Raquel, Fernandes, Jansen, Torres Aleman, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823242/
https://www.ncbi.nlm.nih.gov/pubmed/36636477
http://dx.doi.org/10.12688/f1000research.121901.3

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