An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide

Furosemide (FUR), an active pharmaceutical ingredient (API) belonging to a group of drugs known as loop diuretics, has widespread use, but, is characterized by a strong instability to light, which causes chemical transformations that could give a yellowing phenomenon and have a significant impact fr...

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Detalles Bibliográficos
Autores principales: Giannetti, Micaela, Canale, Viviana Claudia, Micheli, Laura, Fiori, Maurizio, Mazzuca, Claudia, Palleschi, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823353/
https://www.ncbi.nlm.nih.gov/pubmed/36615575
http://dx.doi.org/10.3390/molecules28010381
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author Giannetti, Micaela
Canale, Viviana Claudia
Micheli, Laura
Fiori, Maurizio
Mazzuca, Claudia
Palleschi, Antonio
author_facet Giannetti, Micaela
Canale, Viviana Claudia
Micheli, Laura
Fiori, Maurizio
Mazzuca, Claudia
Palleschi, Antonio
author_sort Giannetti, Micaela
collection PubMed
description Furosemide (FUR), an active pharmaceutical ingredient (API) belonging to a group of drugs known as loop diuretics, has widespread use, but, is characterized by a strong instability to light, which causes chemical transformations that could give a yellowing phenomenon and have a significant impact from a health and marketing point of view. Many studies have tried to explain this phenomenon under different experimental conditions, but no detailed explanation of the yellowing phenomenon has been provided. This work, unlike the others, provides an overall view and explanation of the behavior of FUR in relation to the yellowing phenomenon, both in the solution and in solid state, considering several aspects, such as light exposure, presence of oxygen, and moisture effects.
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spelling pubmed-98233532023-01-08 An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide Giannetti, Micaela Canale, Viviana Claudia Micheli, Laura Fiori, Maurizio Mazzuca, Claudia Palleschi, Antonio Molecules Article Furosemide (FUR), an active pharmaceutical ingredient (API) belonging to a group of drugs known as loop diuretics, has widespread use, but, is characterized by a strong instability to light, which causes chemical transformations that could give a yellowing phenomenon and have a significant impact from a health and marketing point of view. Many studies have tried to explain this phenomenon under different experimental conditions, but no detailed explanation of the yellowing phenomenon has been provided. This work, unlike the others, provides an overall view and explanation of the behavior of FUR in relation to the yellowing phenomenon, both in the solution and in solid state, considering several aspects, such as light exposure, presence of oxygen, and moisture effects. MDPI 2023-01-02 /pmc/articles/PMC9823353/ /pubmed/36615575 http://dx.doi.org/10.3390/molecules28010381 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Giannetti, Micaela
Canale, Viviana Claudia
Micheli, Laura
Fiori, Maurizio
Mazzuca, Claudia
Palleschi, Antonio
An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide
title An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide
title_full An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide
title_fullStr An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide
title_full_unstemmed An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide
title_short An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide
title_sort insight into the degradation processes of the anti-hypertensive drug furosemide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823353/
https://www.ncbi.nlm.nih.gov/pubmed/36615575
http://dx.doi.org/10.3390/molecules28010381
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