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Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine
This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The new compound has been obtained from two biologically active compounds, such as isoxaz...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823373/ https://www.ncbi.nlm.nih.gov/pubmed/36616266 http://dx.doi.org/10.3390/plants12010137 |
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author | Ibrayev, Marat K. Nurkenov, Oralgazy A. Rakhimberlinova, Zhanara B. Takibayeva, Altynaray T. Turdybekov, Dastan M. Seilkhanov, Tulegen M. Issabayeva, Meruyert B. Kelmyalene, Assel A. Kezdikbayeva, Assel T. Mendibayeva, Anel Z. |
author_facet | Ibrayev, Marat K. Nurkenov, Oralgazy A. Rakhimberlinova, Zhanara B. Takibayeva, Altynaray T. Turdybekov, Dastan M. Seilkhanov, Tulegen M. Issabayeva, Meruyert B. Kelmyalene, Assel A. Kezdikbayeva, Assel T. Mendibayeva, Anel Z. |
author_sort | Ibrayev, Marat K. |
collection | PubMed |
description | This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The new compound has been obtained from two biologically active compounds, such as isoxazole and cytisine. It has been demonstrated that the reaction led to the single-stage method under very mild conditions to obtain 4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine. This class of compounds is promising for obtaining the new biologically active compounds. This article has examined, in detail, a structure with using the (1)H and (13)C NMR and two-dimensional NMR spectroscopy of COSY ((1)H-(1)H), HMQC ((1)H-(13)C) and HMBC ((1)H-(13)C). As a result, the homo- and heteronuclear spin-spin couplings should be established. The X-ray diffraction analysis has determined the spatial structure of a new derivative based on the cytisine alkaloid. Thus, its hemorheological activity has been studied. |
format | Online Article Text |
id | pubmed-9823373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98233732023-01-08 Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine Ibrayev, Marat K. Nurkenov, Oralgazy A. Rakhimberlinova, Zhanara B. Takibayeva, Altynaray T. Turdybekov, Dastan M. Seilkhanov, Tulegen M. Issabayeva, Meruyert B. Kelmyalene, Assel A. Kezdikbayeva, Assel T. Mendibayeva, Anel Z. Plants (Basel) Article This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The new compound has been obtained from two biologically active compounds, such as isoxazole and cytisine. It has been demonstrated that the reaction led to the single-stage method under very mild conditions to obtain 4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine. This class of compounds is promising for obtaining the new biologically active compounds. This article has examined, in detail, a structure with using the (1)H and (13)C NMR and two-dimensional NMR spectroscopy of COSY ((1)H-(1)H), HMQC ((1)H-(13)C) and HMBC ((1)H-(13)C). As a result, the homo- and heteronuclear spin-spin couplings should be established. The X-ray diffraction analysis has determined the spatial structure of a new derivative based on the cytisine alkaloid. Thus, its hemorheological activity has been studied. MDPI 2022-12-27 /pmc/articles/PMC9823373/ /pubmed/36616266 http://dx.doi.org/10.3390/plants12010137 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ibrayev, Marat K. Nurkenov, Oralgazy A. Rakhimberlinova, Zhanara B. Takibayeva, Altynaray T. Turdybekov, Dastan M. Seilkhanov, Tulegen M. Issabayeva, Meruyert B. Kelmyalene, Assel A. Kezdikbayeva, Assel T. Mendibayeva, Anel Z. Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine |
title | Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine |
title_full | Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine |
title_fullStr | Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine |
title_full_unstemmed | Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine |
title_short | Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine |
title_sort | synthesis, properties and spatial structure of 4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823373/ https://www.ncbi.nlm.nih.gov/pubmed/36616266 http://dx.doi.org/10.3390/plants12010137 |
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