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Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review

Breast cancer (BC) is the most common cancer worldwide. Chemotherapy (CT) is essential for the treatment of BC, but is often accompanied by several side effects, including taste alterations, due to different mechanisms. Although dysgeusia is usually underestimated by clinicians, it is considered ver...

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Autores principales: Pellegrini, Marianna, Merlo, Fabio Dario, Agnello, Elena, Monge, Taira, Devecchi, Andrea, Casalone, Valentina, Montemurro, Filippo, Ghigo, Ezio, Sapino, Anna, Bo, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823517/
https://www.ncbi.nlm.nih.gov/pubmed/36615883
http://dx.doi.org/10.3390/nu15010226
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author Pellegrini, Marianna
Merlo, Fabio Dario
Agnello, Elena
Monge, Taira
Devecchi, Andrea
Casalone, Valentina
Montemurro, Filippo
Ghigo, Ezio
Sapino, Anna
Bo, Simona
author_facet Pellegrini, Marianna
Merlo, Fabio Dario
Agnello, Elena
Monge, Taira
Devecchi, Andrea
Casalone, Valentina
Montemurro, Filippo
Ghigo, Ezio
Sapino, Anna
Bo, Simona
author_sort Pellegrini, Marianna
collection PubMed
description Breast cancer (BC) is the most common cancer worldwide. Chemotherapy (CT) is essential for the treatment of BC, but is often accompanied by several side effects, including taste alterations, due to different mechanisms. Although dysgeusia is usually underestimated by clinicians, it is considered very worrying and disturbing by cancer patients undergoing CT, because it induces changes in dietary choices and social habits, affecting their physical and psychological health, with a profound impact on their quality of life. Several strategies and therapies have been proposed to prevent or alleviate CT-induced dysgeusia. This review aimed to evaluate the available evidence on prevalence, pathophysiological mechanisms, clinical consequences, and strategies for managing dysgeusia in BC patients receiving CT. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASE, and the Cumulative Index to Nursing and Allied Health Literature database, performing a search strategy using database-specific keywords. We found that the literature on this topic is scarce, methodologically limited, and highly heterogeneous in terms of study design and criteria for patient inclusion, making it difficult to obtain definitive results and make recommendations for clinical practice.
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spelling pubmed-98235172023-01-08 Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review Pellegrini, Marianna Merlo, Fabio Dario Agnello, Elena Monge, Taira Devecchi, Andrea Casalone, Valentina Montemurro, Filippo Ghigo, Ezio Sapino, Anna Bo, Simona Nutrients Review Breast cancer (BC) is the most common cancer worldwide. Chemotherapy (CT) is essential for the treatment of BC, but is often accompanied by several side effects, including taste alterations, due to different mechanisms. Although dysgeusia is usually underestimated by clinicians, it is considered very worrying and disturbing by cancer patients undergoing CT, because it induces changes in dietary choices and social habits, affecting their physical and psychological health, with a profound impact on their quality of life. Several strategies and therapies have been proposed to prevent or alleviate CT-induced dysgeusia. This review aimed to evaluate the available evidence on prevalence, pathophysiological mechanisms, clinical consequences, and strategies for managing dysgeusia in BC patients receiving CT. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASE, and the Cumulative Index to Nursing and Allied Health Literature database, performing a search strategy using database-specific keywords. We found that the literature on this topic is scarce, methodologically limited, and highly heterogeneous in terms of study design and criteria for patient inclusion, making it difficult to obtain definitive results and make recommendations for clinical practice. MDPI 2023-01-01 /pmc/articles/PMC9823517/ /pubmed/36615883 http://dx.doi.org/10.3390/nu15010226 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pellegrini, Marianna
Merlo, Fabio Dario
Agnello, Elena
Monge, Taira
Devecchi, Andrea
Casalone, Valentina
Montemurro, Filippo
Ghigo, Ezio
Sapino, Anna
Bo, Simona
Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review
title Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review
title_full Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review
title_fullStr Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review
title_full_unstemmed Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review
title_short Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review
title_sort dysgeusia in patients with breast cancer treated with chemotherapy—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823517/
https://www.ncbi.nlm.nih.gov/pubmed/36615883
http://dx.doi.org/10.3390/nu15010226
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