Cargando…
Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice
Obesity is a serious public health issue worldwide. Growing evidence demonstrates the efficacy of the ketogenic diet (KD) for weight loss, but there may be some adverse side effects such as dyslipidemia and hepatic steatosis. Aerobic exercise is a widely recognized approach for improving these metab...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823610/ https://www.ncbi.nlm.nih.gov/pubmed/36615908 http://dx.doi.org/10.3390/nu15010251 |
_version_ | 1784866202464550912 |
---|---|
author | Yan, Jiabao Ren, Cuiru Dong, Yunlong Wali, Jibran A. Song, Hongjie Zhang, Ying Zhang, Hengrui Kou, Guangning Raubenheimer, David Cui, Zhenwei |
author_facet | Yan, Jiabao Ren, Cuiru Dong, Yunlong Wali, Jibran A. Song, Hongjie Zhang, Ying Zhang, Hengrui Kou, Guangning Raubenheimer, David Cui, Zhenwei |
author_sort | Yan, Jiabao |
collection | PubMed |
description | Obesity is a serious public health issue worldwide. Growing evidence demonstrates the efficacy of the ketogenic diet (KD) for weight loss, but there may be some adverse side effects such as dyslipidemia and hepatic steatosis. Aerobic exercise is a widely recognized approach for improving these metabolic markers. Here we explored the combined impacts of KD and moderate aerobic exercise for an 8-week intervention on body weight and fat loss, serum biomarkers, and hepatic lipid metabolism in a mouse model of high-fat diet-induced obesity. Both KD and KD combined with exercise significantly reduced body weight and fat mass. No significant adverse effects of KD were observed in serum biomarkers or hepatic lipid storage, except for an increase in circulating triglyceride level. However, aerobic exercise lowered serum triglyceride levels, and further ameliorated serum parameters, and hepatic steatosis in KD-fed mice. Moreover, gene and protein expression analysis indicated that KD combined with exercise was associated with increased expression of lipolysis-related genes and protein levels, and reduced expression of lipogenic genes relative to KD without exercise. Overall, our findings for mice indicate that further work on humans might reveal that KD combined with moderate aerobic exercise could be a promising therapeutic strategy for obesity. |
format | Online Article Text |
id | pubmed-9823610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98236102023-01-08 Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice Yan, Jiabao Ren, Cuiru Dong, Yunlong Wali, Jibran A. Song, Hongjie Zhang, Ying Zhang, Hengrui Kou, Guangning Raubenheimer, David Cui, Zhenwei Nutrients Article Obesity is a serious public health issue worldwide. Growing evidence demonstrates the efficacy of the ketogenic diet (KD) for weight loss, but there may be some adverse side effects such as dyslipidemia and hepatic steatosis. Aerobic exercise is a widely recognized approach for improving these metabolic markers. Here we explored the combined impacts of KD and moderate aerobic exercise for an 8-week intervention on body weight and fat loss, serum biomarkers, and hepatic lipid metabolism in a mouse model of high-fat diet-induced obesity. Both KD and KD combined with exercise significantly reduced body weight and fat mass. No significant adverse effects of KD were observed in serum biomarkers or hepatic lipid storage, except for an increase in circulating triglyceride level. However, aerobic exercise lowered serum triglyceride levels, and further ameliorated serum parameters, and hepatic steatosis in KD-fed mice. Moreover, gene and protein expression analysis indicated that KD combined with exercise was associated with increased expression of lipolysis-related genes and protein levels, and reduced expression of lipogenic genes relative to KD without exercise. Overall, our findings for mice indicate that further work on humans might reveal that KD combined with moderate aerobic exercise could be a promising therapeutic strategy for obesity. MDPI 2023-01-03 /pmc/articles/PMC9823610/ /pubmed/36615908 http://dx.doi.org/10.3390/nu15010251 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yan, Jiabao Ren, Cuiru Dong, Yunlong Wali, Jibran A. Song, Hongjie Zhang, Ying Zhang, Hengrui Kou, Guangning Raubenheimer, David Cui, Zhenwei Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice |
title | Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice |
title_full | Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice |
title_fullStr | Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice |
title_full_unstemmed | Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice |
title_short | Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice |
title_sort | ketogenic diet combined with moderate aerobic exercise training ameliorates white adipose tissue mass, serum biomarkers, and hepatic lipid metabolism in high-fat diet-induced obese mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823610/ https://www.ncbi.nlm.nih.gov/pubmed/36615908 http://dx.doi.org/10.3390/nu15010251 |
work_keys_str_mv | AT yanjiabao ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT rencuiru ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT dongyunlong ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT walijibrana ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT songhongjie ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT zhangying ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT zhanghengrui ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT kouguangning ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT raubenheimerdavid ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice AT cuizhenwei ketogenicdietcombinedwithmoderateaerobicexercisetrainingameliorateswhiteadiposetissuemassserumbiomarkersandhepaticlipidmetabolisminhighfatdietinducedobesemice |