Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study

Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequenci...

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Autores principales: Anchesi, Ivan, Betto, Federica, Chiricosta, Luigi, Gugliandolo, Agnese, Pollastro, Federica, Salamone, Stefano, Mazzon, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823669/
https://www.ncbi.nlm.nih.gov/pubmed/36616322
http://dx.doi.org/10.3390/plants12010193
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author Anchesi, Ivan
Betto, Federica
Chiricosta, Luigi
Gugliandolo, Agnese
Pollastro, Federica
Salamone, Stefano
Mazzon, Emanuela
author_facet Anchesi, Ivan
Betto, Federica
Chiricosta, Luigi
Gugliandolo, Agnese
Pollastro, Federica
Salamone, Stefano
Mazzon, Emanuela
author_sort Anchesi, Ivan
collection PubMed
description Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.
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spelling pubmed-98236692023-01-08 Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study Anchesi, Ivan Betto, Federica Chiricosta, Luigi Gugliandolo, Agnese Pollastro, Federica Salamone, Stefano Mazzon, Emanuela Plants (Basel) Article Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance. MDPI 2023-01-03 /pmc/articles/PMC9823669/ /pubmed/36616322 http://dx.doi.org/10.3390/plants12010193 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anchesi, Ivan
Betto, Federica
Chiricosta, Luigi
Gugliandolo, Agnese
Pollastro, Federica
Salamone, Stefano
Mazzon, Emanuela
Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
title Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
title_full Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
title_fullStr Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
title_full_unstemmed Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
title_short Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
title_sort cannabigerol activates cytoskeletal remodeling via wnt/pcp in nsc-34: an in vitro transcriptional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823669/
https://www.ncbi.nlm.nih.gov/pubmed/36616322
http://dx.doi.org/10.3390/plants12010193
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