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Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications

Mulberry (Morus spp.) is primarily used in sericulture, and its uses also extend to the food, pharmaceutical, and cosmetic industries. Mulberry extracts are rich in many bioactive compounds that exhibit a wide range of biological properties. Mulberroside F (Moracin M-6, 3′-di-O-β-D-glucopyranoside),...

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Autores principales: Thamrongwatwongsa, Jiralapat, Pattarapipatkul, Nattaya, Jaithon, Titiradsadakorn, Jindaruk, Ananya, Paemanee, Atchara, T-Thienprasert, Nattanan Panjaworayan, Phonphoem, Wannarat Pornsiriwong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823754/
https://www.ncbi.nlm.nih.gov/pubmed/36616275
http://dx.doi.org/10.3390/plants12010146
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author Thamrongwatwongsa, Jiralapat
Pattarapipatkul, Nattaya
Jaithon, Titiradsadakorn
Jindaruk, Ananya
Paemanee, Atchara
T-Thienprasert, Nattanan Panjaworayan
Phonphoem, Wannarat Pornsiriwong
author_facet Thamrongwatwongsa, Jiralapat
Pattarapipatkul, Nattaya
Jaithon, Titiradsadakorn
Jindaruk, Ananya
Paemanee, Atchara
T-Thienprasert, Nattanan Panjaworayan
Phonphoem, Wannarat Pornsiriwong
author_sort Thamrongwatwongsa, Jiralapat
collection PubMed
description Mulberry (Morus spp.) is primarily used in sericulture, and its uses also extend to the food, pharmaceutical, and cosmetic industries. Mulberry extracts are rich in many bioactive compounds that exhibit a wide range of biological properties. Mulberroside F (Moracin M-6, 3′-di-O-β-D-glucopyranoside), one of the bioactive compounds found in mulberry, has previously been reported as a whitening agent by inhibiting melanin synthesis and exhibiting antioxidant effects. However, there is still limited information on the presence of this compound in plants cultured in vitro. In this study, the mulberroside F content, biochemical, and cytotoxic properties of the extracts from mulberry cultured in vitro were determined. The results revealed that both root and callus were found to be a potential source of mulberroside F. Furthermore, the mulberroside F content was positively correlated with the inhibitory effects on tyrosinase activity. Cell viability assay also revealed that crude extract of the mulberry root has no cytotoxicity in both human keratinocyte cell line (HaCaT) and Vero cells. Taken together, mulberry tissue culture represents a possible alternative and continuous production of mulberroside F, which could be further utilized in cosmeceutical applications.
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spelling pubmed-98237542023-01-08 Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications Thamrongwatwongsa, Jiralapat Pattarapipatkul, Nattaya Jaithon, Titiradsadakorn Jindaruk, Ananya Paemanee, Atchara T-Thienprasert, Nattanan Panjaworayan Phonphoem, Wannarat Pornsiriwong Plants (Basel) Article Mulberry (Morus spp.) is primarily used in sericulture, and its uses also extend to the food, pharmaceutical, and cosmetic industries. Mulberry extracts are rich in many bioactive compounds that exhibit a wide range of biological properties. Mulberroside F (Moracin M-6, 3′-di-O-β-D-glucopyranoside), one of the bioactive compounds found in mulberry, has previously been reported as a whitening agent by inhibiting melanin synthesis and exhibiting antioxidant effects. However, there is still limited information on the presence of this compound in plants cultured in vitro. In this study, the mulberroside F content, biochemical, and cytotoxic properties of the extracts from mulberry cultured in vitro were determined. The results revealed that both root and callus were found to be a potential source of mulberroside F. Furthermore, the mulberroside F content was positively correlated with the inhibitory effects on tyrosinase activity. Cell viability assay also revealed that crude extract of the mulberry root has no cytotoxicity in both human keratinocyte cell line (HaCaT) and Vero cells. Taken together, mulberry tissue culture represents a possible alternative and continuous production of mulberroside F, which could be further utilized in cosmeceutical applications. MDPI 2022-12-28 /pmc/articles/PMC9823754/ /pubmed/36616275 http://dx.doi.org/10.3390/plants12010146 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thamrongwatwongsa, Jiralapat
Pattarapipatkul, Nattaya
Jaithon, Titiradsadakorn
Jindaruk, Ananya
Paemanee, Atchara
T-Thienprasert, Nattanan Panjaworayan
Phonphoem, Wannarat Pornsiriwong
Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications
title Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications
title_full Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications
title_fullStr Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications
title_full_unstemmed Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications
title_short Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications
title_sort mulberroside f from in vitro culture of mulberry and the potential use of the root extracts in cosmeceutical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823754/
https://www.ncbi.nlm.nih.gov/pubmed/36616275
http://dx.doi.org/10.3390/plants12010146
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