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A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants
Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative compu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823798/ https://www.ncbi.nlm.nih.gov/pubmed/36617042 http://dx.doi.org/10.3390/s23010444 |
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author | Nilsson, Sofie Tokariev, Anton Metsäranta, Marjo Norman, Elisabeth Vanhatalo, Sampsa |
author_facet | Nilsson, Sofie Tokariev, Anton Metsäranta, Marjo Norman, Elisabeth Vanhatalo, Sampsa |
author_sort | Nilsson, Sofie |
collection | PubMed |
description | Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable. Methods: EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27–42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively. Results: The visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612, p = 0.006) and parietal (rho = −0.489, p = 0.035) derivations. The change in ASI was negatively correlated to baseline values in the interhemispheric (rho = −0.753; p = 0.001) and frontal comparisons (rho = −0.496; p = 0.038). Conclusion: Cerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis. |
format | Online Article Text |
id | pubmed-9823798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98237982023-01-08 A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants Nilsson, Sofie Tokariev, Anton Metsäranta, Marjo Norman, Elisabeth Vanhatalo, Sampsa Sensors (Basel) Communication Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable. Methods: EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27–42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively. Results: The visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612, p = 0.006) and parietal (rho = −0.489, p = 0.035) derivations. The change in ASI was negatively correlated to baseline values in the interhemispheric (rho = −0.753; p = 0.001) and frontal comparisons (rho = −0.496; p = 0.038). Conclusion: Cerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis. MDPI 2022-12-31 /pmc/articles/PMC9823798/ /pubmed/36617042 http://dx.doi.org/10.3390/s23010444 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Nilsson, Sofie Tokariev, Anton Metsäranta, Marjo Norman, Elisabeth Vanhatalo, Sampsa A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants |
title | A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants |
title_full | A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants |
title_fullStr | A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants |
title_full_unstemmed | A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants |
title_short | A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants |
title_sort | bedside method for measuring effects of a sedative drug on cerebral function in newborn infants |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823798/ https://www.ncbi.nlm.nih.gov/pubmed/36617042 http://dx.doi.org/10.3390/s23010444 |
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