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High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis
High-fat diets have been identified as a major cause of obesity and a potential risk factor for breast cancer. Fat tissue, also known as adipose tissue, produces an excess of estrogen, which has been linked to an increased risk of breast cancer. Determining the impact of HFDs in the development and...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824074/ https://www.ncbi.nlm.nih.gov/pubmed/36628036 http://dx.doi.org/10.7759/cureus.32309 |
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author | Uhomoibhi, Trinitas Oserefuamen Okobi, Tobechukwu J Okobi, Okelue E Koko, Jovita O Uhomoibhi, Osezimen Igbinosun, Ogie E Ehibor, Uyiosa D Boms, Maureen G Abdulgaffar, Rafiat A Hammed, Bolaji L Ibeanu, Chinenye Segun, Esther O Adeosun, Adeyemi A Evbayekha, Endurance O Alex, Kesena B |
author_facet | Uhomoibhi, Trinitas Oserefuamen Okobi, Tobechukwu J Okobi, Okelue E Koko, Jovita O Uhomoibhi, Osezimen Igbinosun, Ogie E Ehibor, Uyiosa D Boms, Maureen G Abdulgaffar, Rafiat A Hammed, Bolaji L Ibeanu, Chinenye Segun, Esther O Adeosun, Adeyemi A Evbayekha, Endurance O Alex, Kesena B |
author_sort | Uhomoibhi, Trinitas Oserefuamen |
collection | PubMed |
description | High-fat diets have been identified as a major cause of obesity and a potential risk factor for breast cancer. Fat tissue, also known as adipose tissue, produces an excess of estrogen, which has been linked to an increased risk of breast cancer. Determining the impact of HFDs in the development and progression of breast cancer is essential, as it will enable us to identify the role of dietary modification in preventing and managing the disease. The impact of a high-fat diet (HFD) on the development of breast cancer in humans has yet to be fully explained, as very few human studies are available to effectively analyze the effect fatty food has on breast cancer development. This meta-analysis, therefore, seeks to determine the strength of association, if any, between HFD and an increased risk of breast cancer development. This research will help inform good eating habits, potentially reducing the disease's incidence and outcome. This meta-analysis examined eight (8) papers from various nations examining the effect of a high-fat diet as a risk factor for breast cancer development between 2010 and 2020. The study employed the multivariable-adjusted hazard ratio (H.R.), odds ratio (OR), or relative risk (R.R.) from the studies. Breast cancer cases were histologically and radiologically confirmed in the studies evaluated, and validated food frequency questionnaires were used to assess their dietary patterns. This metanalysis study found a substantial link between a high-fat diet and an increased risk of breast cancer, with statistically significant results (I(2) = 93.38%, p0.05). Changes in dietary fat consumption may thus help mitigate some of the unfavorable consequences of breast cancer and survival. Even if further research is needed to support this assertion, the findings are compelling enough to advocate for low-fat, healthy diets to avoid breast cancer. |
format | Online Article Text |
id | pubmed-9824074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-98240742023-01-09 High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis Uhomoibhi, Trinitas Oserefuamen Okobi, Tobechukwu J Okobi, Okelue E Koko, Jovita O Uhomoibhi, Osezimen Igbinosun, Ogie E Ehibor, Uyiosa D Boms, Maureen G Abdulgaffar, Rafiat A Hammed, Bolaji L Ibeanu, Chinenye Segun, Esther O Adeosun, Adeyemi A Evbayekha, Endurance O Alex, Kesena B Cureus Family/General Practice High-fat diets have been identified as a major cause of obesity and a potential risk factor for breast cancer. Fat tissue, also known as adipose tissue, produces an excess of estrogen, which has been linked to an increased risk of breast cancer. Determining the impact of HFDs in the development and progression of breast cancer is essential, as it will enable us to identify the role of dietary modification in preventing and managing the disease. The impact of a high-fat diet (HFD) on the development of breast cancer in humans has yet to be fully explained, as very few human studies are available to effectively analyze the effect fatty food has on breast cancer development. This meta-analysis, therefore, seeks to determine the strength of association, if any, between HFD and an increased risk of breast cancer development. This research will help inform good eating habits, potentially reducing the disease's incidence and outcome. This meta-analysis examined eight (8) papers from various nations examining the effect of a high-fat diet as a risk factor for breast cancer development between 2010 and 2020. The study employed the multivariable-adjusted hazard ratio (H.R.), odds ratio (OR), or relative risk (R.R.) from the studies. Breast cancer cases were histologically and radiologically confirmed in the studies evaluated, and validated food frequency questionnaires were used to assess their dietary patterns. This metanalysis study found a substantial link between a high-fat diet and an increased risk of breast cancer, with statistically significant results (I(2) = 93.38%, p0.05). Changes in dietary fat consumption may thus help mitigate some of the unfavorable consequences of breast cancer and survival. Even if further research is needed to support this assertion, the findings are compelling enough to advocate for low-fat, healthy diets to avoid breast cancer. Cureus 2022-12-08 /pmc/articles/PMC9824074/ /pubmed/36628036 http://dx.doi.org/10.7759/cureus.32309 Text en Copyright © 2022, Uhomoibhi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Family/General Practice Uhomoibhi, Trinitas Oserefuamen Okobi, Tobechukwu J Okobi, Okelue E Koko, Jovita O Uhomoibhi, Osezimen Igbinosun, Ogie E Ehibor, Uyiosa D Boms, Maureen G Abdulgaffar, Rafiat A Hammed, Bolaji L Ibeanu, Chinenye Segun, Esther O Adeosun, Adeyemi A Evbayekha, Endurance O Alex, Kesena B High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis |
title | High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis |
title_full | High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis |
title_fullStr | High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis |
title_full_unstemmed | High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis |
title_short | High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis |
title_sort | high-fat diet as a risk factor for breast cancer: a meta-analysis |
topic | Family/General Practice |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824074/ https://www.ncbi.nlm.nih.gov/pubmed/36628036 http://dx.doi.org/10.7759/cureus.32309 |
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