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Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease

Selenium (Se), an essential antioxidant trace element, is reported to play a role in Parkinson’s disease (PD). However, there is a lack of systematic studies on different Se forms against PD. Our study is designed to compare the neuroprotective effects of inorganic and organic Se in two classical PD...

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Autores principales: Sun, Chongchong, Du, Zhongrui, Liu, Xin, Yang, Ye, Zhou, Sainan, Li, Chong, Cao, Xu, Zhao, Qing, Wong, Kahing, Chen, Wenfang, Dong, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824164/
https://www.ncbi.nlm.nih.gov/pubmed/36615668
http://dx.doi.org/10.3390/nu15010011
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author Sun, Chongchong
Du, Zhongrui
Liu, Xin
Yang, Ye
Zhou, Sainan
Li, Chong
Cao, Xu
Zhao, Qing
Wong, Kahing
Chen, Wenfang
Dong, Xiaoli
author_facet Sun, Chongchong
Du, Zhongrui
Liu, Xin
Yang, Ye
Zhou, Sainan
Li, Chong
Cao, Xu
Zhao, Qing
Wong, Kahing
Chen, Wenfang
Dong, Xiaoli
author_sort Sun, Chongchong
collection PubMed
description Selenium (Se), an essential antioxidant trace element, is reported to play a role in Parkinson’s disease (PD). However, there is a lack of systematic studies on different Se forms against PD. Our study is designed to compare the neuroprotective effects of inorganic and organic Se in two classical PD mice models and investigate the underlying mechanisms for their potentially differential actions against PD. In this study, different dosages of inorganic sodium selenite (Se-Na) or organic seleno-L-methionine (Se-Met) were fed to either acute or chronic PD mice models, and their neuroprotective effects and mechanisms were explored and compared. Se-Na provided better neuroprotective effects in PD mice than Se-Met administered at the same but at a relatively low Se dosage. Se-Na treatment could influence GPX activities but not their mRNA expressions in the midbrains of PD mice. The enhanced GPX activities caused by Se-Na, but not Se-Met, in PD mice could be the major reason for the positive actions of inorganic Se to prevent dopaminergic neuronal loss in this study. In vivo bio-distribution experiments found MPTP injection greatly changed Se bio-distribution in mice, which led to reversed alterations in the bioavailability of Se-Met and Se-Na. Se-Na had higher bioavailability than Se-Met in PD mice, which could explain its better neuroprotective effects compared to Se-Met. Our results proved that Se forms and dosages determined their biological actions in mouse models of PD. Our study will provide valuable scientific evidence to researchers and/or medical professionals in using Se for PD prevention or therapy.
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spelling pubmed-98241642023-01-08 Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease Sun, Chongchong Du, Zhongrui Liu, Xin Yang, Ye Zhou, Sainan Li, Chong Cao, Xu Zhao, Qing Wong, Kahing Chen, Wenfang Dong, Xiaoli Nutrients Article Selenium (Se), an essential antioxidant trace element, is reported to play a role in Parkinson’s disease (PD). However, there is a lack of systematic studies on different Se forms against PD. Our study is designed to compare the neuroprotective effects of inorganic and organic Se in two classical PD mice models and investigate the underlying mechanisms for their potentially differential actions against PD. In this study, different dosages of inorganic sodium selenite (Se-Na) or organic seleno-L-methionine (Se-Met) were fed to either acute or chronic PD mice models, and their neuroprotective effects and mechanisms were explored and compared. Se-Na provided better neuroprotective effects in PD mice than Se-Met administered at the same but at a relatively low Se dosage. Se-Na treatment could influence GPX activities but not their mRNA expressions in the midbrains of PD mice. The enhanced GPX activities caused by Se-Na, but not Se-Met, in PD mice could be the major reason for the positive actions of inorganic Se to prevent dopaminergic neuronal loss in this study. In vivo bio-distribution experiments found MPTP injection greatly changed Se bio-distribution in mice, which led to reversed alterations in the bioavailability of Se-Met and Se-Na. Se-Na had higher bioavailability than Se-Met in PD mice, which could explain its better neuroprotective effects compared to Se-Met. Our results proved that Se forms and dosages determined their biological actions in mouse models of PD. Our study will provide valuable scientific evidence to researchers and/or medical professionals in using Se for PD prevention or therapy. MDPI 2022-12-20 /pmc/articles/PMC9824164/ /pubmed/36615668 http://dx.doi.org/10.3390/nu15010011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Chongchong
Du, Zhongrui
Liu, Xin
Yang, Ye
Zhou, Sainan
Li, Chong
Cao, Xu
Zhao, Qing
Wong, Kahing
Chen, Wenfang
Dong, Xiaoli
Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease
title Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease
title_full Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease
title_fullStr Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease
title_full_unstemmed Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease
title_short Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease
title_sort selenium forms and dosages determined their biological actions in mouse models of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824164/
https://www.ncbi.nlm.nih.gov/pubmed/36615668
http://dx.doi.org/10.3390/nu15010011
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