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New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from t...

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Autores principales: Li, Zhipeng, Ke, Xiyang, Zuo, Dan, Wang, Zhicheng, Fang, Fang, Li, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824372/
https://www.ncbi.nlm.nih.gov/pubmed/36615706
http://dx.doi.org/10.3390/nu15010048
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author Li, Zhipeng
Ke, Xiyang
Zuo, Dan
Wang, Zhicheng
Fang, Fang
Li, Bo
author_facet Li, Zhipeng
Ke, Xiyang
Zuo, Dan
Wang, Zhicheng
Fang, Fang
Li, Bo
author_sort Li, Zhipeng
collection PubMed
description Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments for cancer. In a nutshell, the modifications of the gut microbiota caused by radiotherapy have an effect on tumor radiosensitivity and, as a result, affect the efficacy of radiotherapy and show a certain radiation toxicity, which leads to numerous side effects. What is of new research significance is that the “gut-organ axis” formed by the gut microbiota may be one of the most interesting potential mechanisms, although the relevant research is still very limited. In this review, we combine new insights into the relationship between the gut microbiota, cancer, and radiotherapy. Based on our current comprehensive understanding of this relationship, we give an overview of the new cancer treatments based on the gut microbiota.
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spelling pubmed-98243722023-01-08 New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer Li, Zhipeng Ke, Xiyang Zuo, Dan Wang, Zhicheng Fang, Fang Li, Bo Nutrients Review Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments for cancer. In a nutshell, the modifications of the gut microbiota caused by radiotherapy have an effect on tumor radiosensitivity and, as a result, affect the efficacy of radiotherapy and show a certain radiation toxicity, which leads to numerous side effects. What is of new research significance is that the “gut-organ axis” formed by the gut microbiota may be one of the most interesting potential mechanisms, although the relevant research is still very limited. In this review, we combine new insights into the relationship between the gut microbiota, cancer, and radiotherapy. Based on our current comprehensive understanding of this relationship, we give an overview of the new cancer treatments based on the gut microbiota. MDPI 2022-12-22 /pmc/articles/PMC9824372/ /pubmed/36615706 http://dx.doi.org/10.3390/nu15010048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Zhipeng
Ke, Xiyang
Zuo, Dan
Wang, Zhicheng
Fang, Fang
Li, Bo
New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer
title New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer
title_full New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer
title_fullStr New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer
title_full_unstemmed New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer
title_short New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer
title_sort new insights into the relationship between gut microbiota and radiotherapy for cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824372/
https://www.ncbi.nlm.nih.gov/pubmed/36615706
http://dx.doi.org/10.3390/nu15010048
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