Cargando…

The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Recently, the impact of patients’ eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Res...

Descripción completa

Detalles Bibliográficos
Autores principales: Tiberio, Paola, Antunovic, Lidija, Gaudio, Mariangela, Viganò, Alessandro, Pastore, Manuela, Miggiano, Chiara, Jacobs, Flavia, Benvenuti, Chiara, Farina, Elisabetta, Chiti, Arturo, Santoro, Armando, De Sanctis, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824388/
https://www.ncbi.nlm.nih.gov/pubmed/36615868
http://dx.doi.org/10.3390/nu15010211
_version_ 1784866397604544512
author Tiberio, Paola
Antunovic, Lidija
Gaudio, Mariangela
Viganò, Alessandro
Pastore, Manuela
Miggiano, Chiara
Jacobs, Flavia
Benvenuti, Chiara
Farina, Elisabetta
Chiti, Arturo
Santoro, Armando
De Sanctis, Rita
author_facet Tiberio, Paola
Antunovic, Lidija
Gaudio, Mariangela
Viganò, Alessandro
Pastore, Manuela
Miggiano, Chiara
Jacobs, Flavia
Benvenuti, Chiara
Farina, Elisabetta
Chiti, Arturo
Santoro, Armando
De Sanctis, Rita
author_sort Tiberio, Paola
collection PubMed
description Recently, the impact of patients’ eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Response (pCR) to neoadjuvant chemotherapy (NAC). We included stage I–III BC undergoing standard NAC at IRCCS Humanitas Research Hospital, Italy. Patients fulfilled a survey concerning eating/lifestyle behaviors and performed a staging [18]F-FDG positrone emission tomography/computed tomography (PET/CT). In the absence of data on the effects of individual foods, we aggregated drink and food intake for their known inflammatory properties. Data were recorded for 82 women (median age, 48). We found positive correlations between colon mean standardized uptake value (SUV(mean)) and pro-inflammatory drinks (alcohol and spirits; r = +0.33, p < 0.01) and foods (red and cured meats; r = +0.25, p = 0.04), and a significant negative correlation between rectum SUV(mean) and anti-inflammatory foods (fruits and vegetables; r = −0.23, p = 0.04). Furthermore, colon SUV(mean) was significantly lower in patients with pCR compared to non pCR (p = 0.02). Our study showed, for the first time, that patients’ eating habits affected bowel [18]F-FDG uptake and that colon SUV(mean) correlated with pCR, suggesting that PET scan could be an instrument for identifying patients presenting unhealthy behaviors.
format Online
Article
Text
id pubmed-9824388
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98243882023-01-08 The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy Tiberio, Paola Antunovic, Lidija Gaudio, Mariangela Viganò, Alessandro Pastore, Manuela Miggiano, Chiara Jacobs, Flavia Benvenuti, Chiara Farina, Elisabetta Chiti, Arturo Santoro, Armando De Sanctis, Rita Nutrients Article Recently, the impact of patients’ eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Response (pCR) to neoadjuvant chemotherapy (NAC). We included stage I–III BC undergoing standard NAC at IRCCS Humanitas Research Hospital, Italy. Patients fulfilled a survey concerning eating/lifestyle behaviors and performed a staging [18]F-FDG positrone emission tomography/computed tomography (PET/CT). In the absence of data on the effects of individual foods, we aggregated drink and food intake for their known inflammatory properties. Data were recorded for 82 women (median age, 48). We found positive correlations between colon mean standardized uptake value (SUV(mean)) and pro-inflammatory drinks (alcohol and spirits; r = +0.33, p < 0.01) and foods (red and cured meats; r = +0.25, p = 0.04), and a significant negative correlation between rectum SUV(mean) and anti-inflammatory foods (fruits and vegetables; r = −0.23, p = 0.04). Furthermore, colon SUV(mean) was significantly lower in patients with pCR compared to non pCR (p = 0.02). Our study showed, for the first time, that patients’ eating habits affected bowel [18]F-FDG uptake and that colon SUV(mean) correlated with pCR, suggesting that PET scan could be an instrument for identifying patients presenting unhealthy behaviors. MDPI 2023-01-01 /pmc/articles/PMC9824388/ /pubmed/36615868 http://dx.doi.org/10.3390/nu15010211 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tiberio, Paola
Antunovic, Lidija
Gaudio, Mariangela
Viganò, Alessandro
Pastore, Manuela
Miggiano, Chiara
Jacobs, Flavia
Benvenuti, Chiara
Farina, Elisabetta
Chiti, Arturo
Santoro, Armando
De Sanctis, Rita
The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
title The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
title_full The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
title_fullStr The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
title_full_unstemmed The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
title_short The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
title_sort relationship among bowel [18]f-fdg pet uptake, pathological complete response, and eating habits in breast cancer patients undergoing neoadjuvant chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824388/
https://www.ncbi.nlm.nih.gov/pubmed/36615868
http://dx.doi.org/10.3390/nu15010211
work_keys_str_mv AT tiberiopaola therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT antunoviclidija therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT gaudiomariangela therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT viganoalessandro therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT pastoremanuela therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT miggianochiara therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT jacobsflavia therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT benvenutichiara therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT farinaelisabetta therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT chitiarturo therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT santoroarmando therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT desanctisrita therelationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT tiberiopaola relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT antunoviclidija relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT gaudiomariangela relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT viganoalessandro relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT pastoremanuela relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT miggianochiara relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT jacobsflavia relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT benvenutichiara relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT farinaelisabetta relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT chitiarturo relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT santoroarmando relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy
AT desanctisrita relationshipamongbowel18ffdgpetuptakepathologicalcompleteresponseandeatinghabitsinbreastcancerpatientsundergoingneoadjuvantchemotherapy