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The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
Recently, the impact of patients’ eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Res...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824388/ https://www.ncbi.nlm.nih.gov/pubmed/36615868 http://dx.doi.org/10.3390/nu15010211 |
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author | Tiberio, Paola Antunovic, Lidija Gaudio, Mariangela Viganò, Alessandro Pastore, Manuela Miggiano, Chiara Jacobs, Flavia Benvenuti, Chiara Farina, Elisabetta Chiti, Arturo Santoro, Armando De Sanctis, Rita |
author_facet | Tiberio, Paola Antunovic, Lidija Gaudio, Mariangela Viganò, Alessandro Pastore, Manuela Miggiano, Chiara Jacobs, Flavia Benvenuti, Chiara Farina, Elisabetta Chiti, Arturo Santoro, Armando De Sanctis, Rita |
author_sort | Tiberio, Paola |
collection | PubMed |
description | Recently, the impact of patients’ eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Response (pCR) to neoadjuvant chemotherapy (NAC). We included stage I–III BC undergoing standard NAC at IRCCS Humanitas Research Hospital, Italy. Patients fulfilled a survey concerning eating/lifestyle behaviors and performed a staging [18]F-FDG positrone emission tomography/computed tomography (PET/CT). In the absence of data on the effects of individual foods, we aggregated drink and food intake for their known inflammatory properties. Data were recorded for 82 women (median age, 48). We found positive correlations between colon mean standardized uptake value (SUV(mean)) and pro-inflammatory drinks (alcohol and spirits; r = +0.33, p < 0.01) and foods (red and cured meats; r = +0.25, p = 0.04), and a significant negative correlation between rectum SUV(mean) and anti-inflammatory foods (fruits and vegetables; r = −0.23, p = 0.04). Furthermore, colon SUV(mean) was significantly lower in patients with pCR compared to non pCR (p = 0.02). Our study showed, for the first time, that patients’ eating habits affected bowel [18]F-FDG uptake and that colon SUV(mean) correlated with pCR, suggesting that PET scan could be an instrument for identifying patients presenting unhealthy behaviors. |
format | Online Article Text |
id | pubmed-9824388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98243882023-01-08 The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy Tiberio, Paola Antunovic, Lidija Gaudio, Mariangela Viganò, Alessandro Pastore, Manuela Miggiano, Chiara Jacobs, Flavia Benvenuti, Chiara Farina, Elisabetta Chiti, Arturo Santoro, Armando De Sanctis, Rita Nutrients Article Recently, the impact of patients’ eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Response (pCR) to neoadjuvant chemotherapy (NAC). We included stage I–III BC undergoing standard NAC at IRCCS Humanitas Research Hospital, Italy. Patients fulfilled a survey concerning eating/lifestyle behaviors and performed a staging [18]F-FDG positrone emission tomography/computed tomography (PET/CT). In the absence of data on the effects of individual foods, we aggregated drink and food intake for their known inflammatory properties. Data were recorded for 82 women (median age, 48). We found positive correlations between colon mean standardized uptake value (SUV(mean)) and pro-inflammatory drinks (alcohol and spirits; r = +0.33, p < 0.01) and foods (red and cured meats; r = +0.25, p = 0.04), and a significant negative correlation between rectum SUV(mean) and anti-inflammatory foods (fruits and vegetables; r = −0.23, p = 0.04). Furthermore, colon SUV(mean) was significantly lower in patients with pCR compared to non pCR (p = 0.02). Our study showed, for the first time, that patients’ eating habits affected bowel [18]F-FDG uptake and that colon SUV(mean) correlated with pCR, suggesting that PET scan could be an instrument for identifying patients presenting unhealthy behaviors. MDPI 2023-01-01 /pmc/articles/PMC9824388/ /pubmed/36615868 http://dx.doi.org/10.3390/nu15010211 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tiberio, Paola Antunovic, Lidija Gaudio, Mariangela Viganò, Alessandro Pastore, Manuela Miggiano, Chiara Jacobs, Flavia Benvenuti, Chiara Farina, Elisabetta Chiti, Arturo Santoro, Armando De Sanctis, Rita The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy |
title | The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy |
title_full | The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy |
title_fullStr | The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy |
title_full_unstemmed | The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy |
title_short | The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy |
title_sort | relationship among bowel [18]f-fdg pet uptake, pathological complete response, and eating habits in breast cancer patients undergoing neoadjuvant chemotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824388/ https://www.ncbi.nlm.nih.gov/pubmed/36615868 http://dx.doi.org/10.3390/nu15010211 |
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