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Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats
Limosilactobacillus fermentum CECT5716, a probiotic strain isolated from human milk, has reported beneficial effects on different gastrointestinal disorders. Moreover, it has shown its ability to restore altered immune responses, in association with microbiome modulation in different pathological co...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824399/ https://www.ncbi.nlm.nih.gov/pubmed/36615683 http://dx.doi.org/10.3390/nu15010024 |
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author | Rodríguez-Sojo, María Jesús Garcia-Garcia, Jorge Ruiz-Malagón, Antonio Jesús Diez-Echave, Patricia Hidalgo-García, Laura Molina-Tijeras, José Alberto González-Lozano, Elena López-Escanez, Laura Rodríguez-Cabezas, María Elena Rodríguez-Sánchez, Maria José Rodríguez-Nogales, Alba Mediavilla, Cristina Galvez, Julio |
author_facet | Rodríguez-Sojo, María Jesús Garcia-Garcia, Jorge Ruiz-Malagón, Antonio Jesús Diez-Echave, Patricia Hidalgo-García, Laura Molina-Tijeras, José Alberto González-Lozano, Elena López-Escanez, Laura Rodríguez-Cabezas, María Elena Rodríguez-Sánchez, Maria José Rodríguez-Nogales, Alba Mediavilla, Cristina Galvez, Julio |
author_sort | Rodríguez-Sojo, María Jesús |
collection | PubMed |
description | Limosilactobacillus fermentum CECT5716, a probiotic strain isolated from human milk, has reported beneficial effects on different gastrointestinal disorders. Moreover, it has shown its ability to restore altered immune responses, in association with microbiome modulation in different pathological conditions. Therefore, our aim was to assess the effects of a Limosilacbacillus fermentum CECT5716 in a rat experimental model of irritable bowel syndrome (IBS) that resembles human IBS. The experimental IBS was induced by deoxycholic acid (DCA) in rats and then, Limosilactobacillus fermentum CECT5716 (10(9) CFU/day/rat) was administered. Behavioral studies, hyperalgesia and intestinal hypersensitivity determinations were performed and the impact of the probiotic on the inflammatory and intestinal barrier integrity was evaluated. Additionally, the gut microbiota composition was analyzed. Limosilactobacillus fermentum CECT5716 attenuated the anxiety-like behavior as well as the visceral hypersensitivity and referred pain. Moreover, this probiotic ameliorated the gut inflammatory status, re-establishing the altered intestinal permeability, reducing the mast cell degranulation and re-establishing the gut dysbiosis in experimental IBS. Therefore, our results suggest a potential use of Limosilactobacillus fermentum CECT5716 in clinical practice for the management of IBS patients. |
format | Online Article Text |
id | pubmed-9824399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98243992023-01-08 Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats Rodríguez-Sojo, María Jesús Garcia-Garcia, Jorge Ruiz-Malagón, Antonio Jesús Diez-Echave, Patricia Hidalgo-García, Laura Molina-Tijeras, José Alberto González-Lozano, Elena López-Escanez, Laura Rodríguez-Cabezas, María Elena Rodríguez-Sánchez, Maria José Rodríguez-Nogales, Alba Mediavilla, Cristina Galvez, Julio Nutrients Article Limosilactobacillus fermentum CECT5716, a probiotic strain isolated from human milk, has reported beneficial effects on different gastrointestinal disorders. Moreover, it has shown its ability to restore altered immune responses, in association with microbiome modulation in different pathological conditions. Therefore, our aim was to assess the effects of a Limosilacbacillus fermentum CECT5716 in a rat experimental model of irritable bowel syndrome (IBS) that resembles human IBS. The experimental IBS was induced by deoxycholic acid (DCA) in rats and then, Limosilactobacillus fermentum CECT5716 (10(9) CFU/day/rat) was administered. Behavioral studies, hyperalgesia and intestinal hypersensitivity determinations were performed and the impact of the probiotic on the inflammatory and intestinal barrier integrity was evaluated. Additionally, the gut microbiota composition was analyzed. Limosilactobacillus fermentum CECT5716 attenuated the anxiety-like behavior as well as the visceral hypersensitivity and referred pain. Moreover, this probiotic ameliorated the gut inflammatory status, re-establishing the altered intestinal permeability, reducing the mast cell degranulation and re-establishing the gut dysbiosis in experimental IBS. Therefore, our results suggest a potential use of Limosilactobacillus fermentum CECT5716 in clinical practice for the management of IBS patients. MDPI 2022-12-21 /pmc/articles/PMC9824399/ /pubmed/36615683 http://dx.doi.org/10.3390/nu15010024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rodríguez-Sojo, María Jesús Garcia-Garcia, Jorge Ruiz-Malagón, Antonio Jesús Diez-Echave, Patricia Hidalgo-García, Laura Molina-Tijeras, José Alberto González-Lozano, Elena López-Escanez, Laura Rodríguez-Cabezas, María Elena Rodríguez-Sánchez, Maria José Rodríguez-Nogales, Alba Mediavilla, Cristina Galvez, Julio Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats |
title | Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats |
title_full | Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats |
title_fullStr | Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats |
title_full_unstemmed | Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats |
title_short | Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats |
title_sort | beneficial effects of limosilactobacillus fermentum in the dca experimental model of irritable bowel syndrome in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824399/ https://www.ncbi.nlm.nih.gov/pubmed/36615683 http://dx.doi.org/10.3390/nu15010024 |
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