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Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index

We aimed to test the hypothesis that adherence to a healthful plant-based diet (hPDI) is associated with a subsequent decrease in the incidence of asthma symptoms, with an opposite association with adherence to an unhealthful plant-based diet (uPDI). In addition, we evaluated a potential mediating r...

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Autores principales: Ait-hadad, Wassila, Bédard, Annabelle, Delvert, Rosalie, Orsi, Laurent, Chanoine, Sébastien, Dumas, Orianne, Laouali, Nasser, Le Moual, Nicole, Leynaert, Bénédicte, Siroux, Valérie, Boutron-Ruault, Marie-Christine, Varraso, Raphaëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824479/
https://www.ncbi.nlm.nih.gov/pubmed/36615710
http://dx.doi.org/10.3390/nu15010052
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author Ait-hadad, Wassila
Bédard, Annabelle
Delvert, Rosalie
Orsi, Laurent
Chanoine, Sébastien
Dumas, Orianne
Laouali, Nasser
Le Moual, Nicole
Leynaert, Bénédicte
Siroux, Valérie
Boutron-Ruault, Marie-Christine
Varraso, Raphaëlle
author_facet Ait-hadad, Wassila
Bédard, Annabelle
Delvert, Rosalie
Orsi, Laurent
Chanoine, Sébastien
Dumas, Orianne
Laouali, Nasser
Le Moual, Nicole
Leynaert, Bénédicte
Siroux, Valérie
Boutron-Ruault, Marie-Christine
Varraso, Raphaëlle
author_sort Ait-hadad, Wassila
collection PubMed
description We aimed to test the hypothesis that adherence to a healthful plant-based diet (hPDI) is associated with a subsequent decrease in the incidence of asthma symptoms, with an opposite association with adherence to an unhealthful plant-based diet (uPDI). In addition, we evaluated a potential mediating role of body mass index (BMI) and the modifying effect of smoking. Among 5700 elderly women from the French Asthma-E3N study with dietary data in 1993 and 2005, we assessed the incidence of asthma symptoms in 2018 among women with no asthma symptoms in 2011. BMI was evaluated in 2008. Mediation analyses in the counterfactual framework were used to disentangle total, direct, and indirect effects mediated by BMI. We found that both healthful and unhealthful plant-based diets were associated with a lower incidence of asthma symptoms over time, mediated by BMI (OR (95%CI) for the indirect effect: 0.94 (0.89–1.00) for hPDI and 0.92 (0.70–1.00) for uPDI)). Associations with both healthful and unhealthful PDIs were mediated by changes in BMI by 33% and 89%, respectively. Plant-based diets (healthful and unhealthful) were associated with subsequently reduced incidences of asthma symptoms over time, partly or almost totally mediated by BMI according to their nutritional quality.
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spelling pubmed-98244792023-01-08 Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index Ait-hadad, Wassila Bédard, Annabelle Delvert, Rosalie Orsi, Laurent Chanoine, Sébastien Dumas, Orianne Laouali, Nasser Le Moual, Nicole Leynaert, Bénédicte Siroux, Valérie Boutron-Ruault, Marie-Christine Varraso, Raphaëlle Nutrients Article We aimed to test the hypothesis that adherence to a healthful plant-based diet (hPDI) is associated with a subsequent decrease in the incidence of asthma symptoms, with an opposite association with adherence to an unhealthful plant-based diet (uPDI). In addition, we evaluated a potential mediating role of body mass index (BMI) and the modifying effect of smoking. Among 5700 elderly women from the French Asthma-E3N study with dietary data in 1993 and 2005, we assessed the incidence of asthma symptoms in 2018 among women with no asthma symptoms in 2011. BMI was evaluated in 2008. Mediation analyses in the counterfactual framework were used to disentangle total, direct, and indirect effects mediated by BMI. We found that both healthful and unhealthful plant-based diets were associated with a lower incidence of asthma symptoms over time, mediated by BMI (OR (95%CI) for the indirect effect: 0.94 (0.89–1.00) for hPDI and 0.92 (0.70–1.00) for uPDI)). Associations with both healthful and unhealthful PDIs were mediated by changes in BMI by 33% and 89%, respectively. Plant-based diets (healthful and unhealthful) were associated with subsequently reduced incidences of asthma symptoms over time, partly or almost totally mediated by BMI according to their nutritional quality. MDPI 2022-12-22 /pmc/articles/PMC9824479/ /pubmed/36615710 http://dx.doi.org/10.3390/nu15010052 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ait-hadad, Wassila
Bédard, Annabelle
Delvert, Rosalie
Orsi, Laurent
Chanoine, Sébastien
Dumas, Orianne
Laouali, Nasser
Le Moual, Nicole
Leynaert, Bénédicte
Siroux, Valérie
Boutron-Ruault, Marie-Christine
Varraso, Raphaëlle
Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index
title Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index
title_full Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index
title_fullStr Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index
title_full_unstemmed Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index
title_short Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index
title_sort plant-based diets and the incidence of asthma symptoms among elderly women, and the mediating role of body mass index
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824479/
https://www.ncbi.nlm.nih.gov/pubmed/36615710
http://dx.doi.org/10.3390/nu15010052
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