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The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review

Menopause is a physiological change in any woman. Nevertheless, its symptoms could be difficult to accept, and hormone therapy can be sometimes unattractive or contraindicated. Vitamin E components are phytoestrogens, so they are believed to be useful in some indications including menopause. This re...

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Autores principales: Feduniw, Stepan, Korczyńska, Lidia, Górski, Konrad, Zgliczyńska, Magdalena, Bączkowska, Monika, Byrczak, Maciej, Kociuba, Jakub, Ali, Mohamed, Ciebiera, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824658/
https://www.ncbi.nlm.nih.gov/pubmed/36615817
http://dx.doi.org/10.3390/nu15010160
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author Feduniw, Stepan
Korczyńska, Lidia
Górski, Konrad
Zgliczyńska, Magdalena
Bączkowska, Monika
Byrczak, Maciej
Kociuba, Jakub
Ali, Mohamed
Ciebiera, Michał
author_facet Feduniw, Stepan
Korczyńska, Lidia
Górski, Konrad
Zgliczyńska, Magdalena
Bączkowska, Monika
Byrczak, Maciej
Kociuba, Jakub
Ali, Mohamed
Ciebiera, Michał
author_sort Feduniw, Stepan
collection PubMed
description Menopause is a physiological change in any woman. Nevertheless, its symptoms could be difficult to accept, and hormone therapy can be sometimes unattractive or contraindicated. Vitamin E components are phytoestrogens, so they are believed to be useful in some indications including menopause. This review aimed to assess the available evidence on the effectiveness of vitamin E in alleviating menopausal symptoms. The Pubmed/MEDLINE, Cochrane Library and Scopus databases were screened. All types of studies that assessed the effectiveness of vitamin E in alleviating menopausal symptoms were included. The PICO question was: “How does vitamin E supplementation affect menopausal symptom occurrence?” The PROSPERO ID number of this review is CRD42022328830. After quality assessment, 16 studies were included in the analysis. The studies were divided into three groups in which the influence of vitamin E on the genital syndrome of menopause, vasomotor symptoms and vascular and metabolic changes were assessed. Vitamin E influences postmenopausal hot flashes, vascular modulation, plasma lipid profile level and vaginal changes. Compared to vitamin E, estrogen administration leads to better clinical effects. Nevertheless, vitamin E might serve as additive to hormone therapy and its alternative in women with contraindications to estrogens. More quality data are necessary to draw final conclusions.
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spelling pubmed-98246582023-01-08 The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review Feduniw, Stepan Korczyńska, Lidia Górski, Konrad Zgliczyńska, Magdalena Bączkowska, Monika Byrczak, Maciej Kociuba, Jakub Ali, Mohamed Ciebiera, Michał Nutrients Systematic Review Menopause is a physiological change in any woman. Nevertheless, its symptoms could be difficult to accept, and hormone therapy can be sometimes unattractive or contraindicated. Vitamin E components are phytoestrogens, so they are believed to be useful in some indications including menopause. This review aimed to assess the available evidence on the effectiveness of vitamin E in alleviating menopausal symptoms. The Pubmed/MEDLINE, Cochrane Library and Scopus databases were screened. All types of studies that assessed the effectiveness of vitamin E in alleviating menopausal symptoms were included. The PICO question was: “How does vitamin E supplementation affect menopausal symptom occurrence?” The PROSPERO ID number of this review is CRD42022328830. After quality assessment, 16 studies were included in the analysis. The studies were divided into three groups in which the influence of vitamin E on the genital syndrome of menopause, vasomotor symptoms and vascular and metabolic changes were assessed. Vitamin E influences postmenopausal hot flashes, vascular modulation, plasma lipid profile level and vaginal changes. Compared to vitamin E, estrogen administration leads to better clinical effects. Nevertheless, vitamin E might serve as additive to hormone therapy and its alternative in women with contraindications to estrogens. More quality data are necessary to draw final conclusions. MDPI 2022-12-29 /pmc/articles/PMC9824658/ /pubmed/36615817 http://dx.doi.org/10.3390/nu15010160 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Feduniw, Stepan
Korczyńska, Lidia
Górski, Konrad
Zgliczyńska, Magdalena
Bączkowska, Monika
Byrczak, Maciej
Kociuba, Jakub
Ali, Mohamed
Ciebiera, Michał
The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review
title The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review
title_full The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review
title_fullStr The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review
title_full_unstemmed The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review
title_short The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review
title_sort effect of vitamin e supplementation in postmenopausal women—a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824658/
https://www.ncbi.nlm.nih.gov/pubmed/36615817
http://dx.doi.org/10.3390/nu15010160
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