Cargando…

Immune Defences: A View from the Side of the Essential Oils

The use of essential oils is increasingly being investigated among new therapeutic approaches based on medicinal plants and their extracts. With the wide use of synthetic and semi-synthetic antimicrobial drugs, the spread of drug-resistant clinical isolates has increased, and research is directed to...

Descripción completa

Detalles Bibliográficos
Autores principales: Tullio, Vivian, Roana, Janira, Cavallo, Lorenza, Mandras, Narcisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824899/
https://www.ncbi.nlm.nih.gov/pubmed/36615625
http://dx.doi.org/10.3390/molecules28010435
_version_ 1784866523412692992
author Tullio, Vivian
Roana, Janira
Cavallo, Lorenza
Mandras, Narcisa
author_facet Tullio, Vivian
Roana, Janira
Cavallo, Lorenza
Mandras, Narcisa
author_sort Tullio, Vivian
collection PubMed
description The use of essential oils is increasingly being investigated among new therapeutic approaches based on medicinal plants and their extracts. With the wide use of synthetic and semi-synthetic antimicrobial drugs, the spread of drug-resistant clinical isolates has increased, and research is directed towards natural products, such as essential oils, as useful antimicrobial resources. In the context of a prospective infection, we compared the impact of essential oils and common antimicrobial agents on the microbicidal activity of human phagocytes. Here, we present the results of our decades-long investigation into the effectiveness of thyme red oil (26.52% thymol chemotype), tea tree oil (TTO), and Mentha of Pancalieri [(Mentha x piperita (Huds) var. officinalis (Sole), form rubescens (Camus) (Lamiaceae)] essential oils on human polymorphonuclear leukocytes (PMNs) capacity to kill clinical strains of Candida albicans and C. krusei when compared to three antifungal drugs used to treat candidiasis (fluconazole, anidulafungin, and caspofungin) These essential oils demonstrate antifungal drug-like and/or superior efficacy in enhancing intracellular killing by PMNs, even at subinhibitory concentrations. Our results are compared with data in the literature on essential oils and immune system interactions. This comparison would aid in identifying therapeutic solutions to the increasingly prevalent antibiotic resistance as well as filling in any remaining knowledge gaps on the bioactivity of essential oils.
format Online
Article
Text
id pubmed-9824899
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98248992023-01-08 Immune Defences: A View from the Side of the Essential Oils Tullio, Vivian Roana, Janira Cavallo, Lorenza Mandras, Narcisa Molecules Review The use of essential oils is increasingly being investigated among new therapeutic approaches based on medicinal plants and their extracts. With the wide use of synthetic and semi-synthetic antimicrobial drugs, the spread of drug-resistant clinical isolates has increased, and research is directed towards natural products, such as essential oils, as useful antimicrobial resources. In the context of a prospective infection, we compared the impact of essential oils and common antimicrobial agents on the microbicidal activity of human phagocytes. Here, we present the results of our decades-long investigation into the effectiveness of thyme red oil (26.52% thymol chemotype), tea tree oil (TTO), and Mentha of Pancalieri [(Mentha x piperita (Huds) var. officinalis (Sole), form rubescens (Camus) (Lamiaceae)] essential oils on human polymorphonuclear leukocytes (PMNs) capacity to kill clinical strains of Candida albicans and C. krusei when compared to three antifungal drugs used to treat candidiasis (fluconazole, anidulafungin, and caspofungin) These essential oils demonstrate antifungal drug-like and/or superior efficacy in enhancing intracellular killing by PMNs, even at subinhibitory concentrations. Our results are compared with data in the literature on essential oils and immune system interactions. This comparison would aid in identifying therapeutic solutions to the increasingly prevalent antibiotic resistance as well as filling in any remaining knowledge gaps on the bioactivity of essential oils. MDPI 2023-01-03 /pmc/articles/PMC9824899/ /pubmed/36615625 http://dx.doi.org/10.3390/molecules28010435 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tullio, Vivian
Roana, Janira
Cavallo, Lorenza
Mandras, Narcisa
Immune Defences: A View from the Side of the Essential Oils
title Immune Defences: A View from the Side of the Essential Oils
title_full Immune Defences: A View from the Side of the Essential Oils
title_fullStr Immune Defences: A View from the Side of the Essential Oils
title_full_unstemmed Immune Defences: A View from the Side of the Essential Oils
title_short Immune Defences: A View from the Side of the Essential Oils
title_sort immune defences: a view from the side of the essential oils
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824899/
https://www.ncbi.nlm.nih.gov/pubmed/36615625
http://dx.doi.org/10.3390/molecules28010435
work_keys_str_mv AT tulliovivian immunedefencesaviewfromthesideoftheessentialoils
AT roanajanira immunedefencesaviewfromthesideoftheessentialoils
AT cavallolorenza immunedefencesaviewfromthesideoftheessentialoils
AT mandrasnarcisa immunedefencesaviewfromthesideoftheessentialoils