Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

BACKGROUND: Alzheimer’s disease (AD) is neuropathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks include Aβ40, Aβ42, tau, phosphor-tau, and APOE. We hypothesize that genetic variants influence the levels and solubility...

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Detalles Bibliográficos
Autores principales: Oatman, Stephanie R., Reddy, Joseph S., Quicksall, Zachary, Carrasquillo, Minerva M., Wang, Xue, Liu, Chia-Chen, Yamazaki, Yu, Nguyen, Thuy T., Malphrus, Kimberly, Heckman, Michael, Biswas, Kristi, Nho, Kwangsik, Baker, Matthew, Martens, Yuka A., Zhao, Na, Kim, Jun Pyo, Risacher, Shannon L., Rademakers, Rosa, Saykin, Andrew J., DeTure, Michael, Murray, Melissa E., Kanekiyo, Takahisa, Dickson, Dennis W., Bu, Guojun, Allen, Mariet, Ertekin-Taner, Nilüfer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825010/
https://www.ncbi.nlm.nih.gov/pubmed/36609403
http://dx.doi.org/10.1186/s13024-022-00592-2

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