Cargando…
Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations
BACKGROUND: The GJB2 gene is reported to be the main hereditary factor responsible for non-syndromic hearing impairment in infants. Several kinds of hearing loss have been linked to elevated inflammatory markers. This study aimed to evaluate serum levels of IL-2, IL-4, IL-6, IL-10, IL-17, α-TNF, and...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825025/ https://www.ncbi.nlm.nih.gov/pubmed/36593740 http://dx.doi.org/10.12659/MSM.938165 |
_version_ | 1784866551301668864 |
---|---|
author | Zhang, Xingang Ma, Zhaoxin Zheng, Jishan Xu, Huiqing Pan, Jiewen Lv, Lanqiu |
author_facet | Zhang, Xingang Ma, Zhaoxin Zheng, Jishan Xu, Huiqing Pan, Jiewen Lv, Lanqiu |
author_sort | Zhang, Xingang |
collection | PubMed |
description | BACKGROUND: The GJB2 gene is reported to be the main hereditary factor responsible for non-syndromic hearing impairment in infants. Several kinds of hearing loss have been linked to elevated inflammatory markers. This study aimed to evaluate serum levels of IL-2, IL-4, IL-6, IL-10, IL-17, α-TNF, and γ-IFN and the severity of hearing loss. MATERIAL/METHODS: Ninety newborns were divided into 3 groups: severe hearing impairment (31 infants), moderate hearing impairment (30 infants), and normal hearing (29 infants). Hearing screening was performed using otoacoustic emissions test. Mutations of the GJB2 gene were detected with Sanger sequencing. The patients had DNFB1 mutation. Seven blood inflammatory markers were tested using Cytometric Bead Array. We performed the t test to examine differences in expression of 7 inflammatory markers between sexes in the groups. The correlation between indicators within groups was studied using the Pearson correlation test. Correlation of different indicators among groups was studied using the Spearman correlation test. RESULTS: When compared among the 3 groups (severe, moderate hearing impairment, and normal hearing group), we found that IL-10 had a positive correlation with the severity of GJB2-associated hearing loss, which was statistically significant (P<0.05). CONCLUSIONS: This research aimed to assess the relationship of 7 serum inflammatory markers with GJB2-associated hearing loss in infants. Inflammatory marker IL-10 had a positive correlation with the severity of GJB2-associated infant hearing loss, and it might have the potential to become a future therapeutic target. |
format | Online Article Text |
id | pubmed-9825025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98250252023-01-20 Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations Zhang, Xingang Ma, Zhaoxin Zheng, Jishan Xu, Huiqing Pan, Jiewen Lv, Lanqiu Med Sci Monit Clinical Research BACKGROUND: The GJB2 gene is reported to be the main hereditary factor responsible for non-syndromic hearing impairment in infants. Several kinds of hearing loss have been linked to elevated inflammatory markers. This study aimed to evaluate serum levels of IL-2, IL-4, IL-6, IL-10, IL-17, α-TNF, and γ-IFN and the severity of hearing loss. MATERIAL/METHODS: Ninety newborns were divided into 3 groups: severe hearing impairment (31 infants), moderate hearing impairment (30 infants), and normal hearing (29 infants). Hearing screening was performed using otoacoustic emissions test. Mutations of the GJB2 gene were detected with Sanger sequencing. The patients had DNFB1 mutation. Seven blood inflammatory markers were tested using Cytometric Bead Array. We performed the t test to examine differences in expression of 7 inflammatory markers between sexes in the groups. The correlation between indicators within groups was studied using the Pearson correlation test. Correlation of different indicators among groups was studied using the Spearman correlation test. RESULTS: When compared among the 3 groups (severe, moderate hearing impairment, and normal hearing group), we found that IL-10 had a positive correlation with the severity of GJB2-associated hearing loss, which was statistically significant (P<0.05). CONCLUSIONS: This research aimed to assess the relationship of 7 serum inflammatory markers with GJB2-associated hearing loss in infants. Inflammatory marker IL-10 had a positive correlation with the severity of GJB2-associated infant hearing loss, and it might have the potential to become a future therapeutic target. International Scientific Literature, Inc. 2023-01-03 /pmc/articles/PMC9825025/ /pubmed/36593740 http://dx.doi.org/10.12659/MSM.938165 Text en © Med Sci Monit, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Zhang, Xingang Ma, Zhaoxin Zheng, Jishan Xu, Huiqing Pan, Jiewen Lv, Lanqiu Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations |
title | Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations |
title_full | Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations |
title_fullStr | Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations |
title_full_unstemmed | Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations |
title_short | Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations |
title_sort | analysis of serum inflammatory markers in infants under 6 months of age with non-syndromic moderate and severe hearing loss associated with gjb2 gene mutations |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825025/ https://www.ncbi.nlm.nih.gov/pubmed/36593740 http://dx.doi.org/10.12659/MSM.938165 |
work_keys_str_mv | AT zhangxingang analysisofseruminflammatorymarkersininfantsunder6monthsofagewithnonsyndromicmoderateandseverehearinglossassociatedwithgjb2genemutations AT mazhaoxin analysisofseruminflammatorymarkersininfantsunder6monthsofagewithnonsyndromicmoderateandseverehearinglossassociatedwithgjb2genemutations AT zhengjishan analysisofseruminflammatorymarkersininfantsunder6monthsofagewithnonsyndromicmoderateandseverehearinglossassociatedwithgjb2genemutations AT xuhuiqing analysisofseruminflammatorymarkersininfantsunder6monthsofagewithnonsyndromicmoderateandseverehearinglossassociatedwithgjb2genemutations AT panjiewen analysisofseruminflammatorymarkersininfantsunder6monthsofagewithnonsyndromicmoderateandseverehearinglossassociatedwithgjb2genemutations AT lvlanqiu analysisofseruminflammatorymarkersininfantsunder6monthsofagewithnonsyndromicmoderateandseverehearinglossassociatedwithgjb2genemutations |