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Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine

ABSTRACT: In December 2019, the world experienced a new coronavirus, SARS-CoV-2, causing coronavirus disease 2019 originating from Wuhan.The virus has crossed national borders and now affects more than 200 countries and territories. Hydroxychloroquine has been considered as a drug capable of treatin...

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Autores principales: Zoubir, Jallal, Bakas, Idriss, Qourzal, Samir, Tamimi, Malika, Assabbane, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825087/
https://www.ncbi.nlm.nih.gov/pubmed/36644408
http://dx.doi.org/10.1007/s10800-022-01835-2
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author Zoubir, Jallal
Bakas, Idriss
Qourzal, Samir
Tamimi, Malika
Assabbane, Ali
author_facet Zoubir, Jallal
Bakas, Idriss
Qourzal, Samir
Tamimi, Malika
Assabbane, Ali
author_sort Zoubir, Jallal
collection PubMed
description ABSTRACT: In December 2019, the world experienced a new coronavirus, SARS-CoV-2, causing coronavirus disease 2019 originating from Wuhan.The virus has crossed national borders and now affects more than 200 countries and territories. Hydroxychloroquine has been considered as a drug capable of treating COVID-19. The objective of this work is to establish a simple platform for electrocatalytic detection of hydroxychloroquine in human urine samples and pharmaceutical samples (tablets) using a ZnO@CPE sensor constructed by simple and inexpensive hydrothermal methods using a square wave voltammetry method. The best results are obtained in a PBS electrolyte with irreversible behavior of the hydroxychloroquine complement and controlled by diffusion coupled with absorption phenomena. The ZnO@CPE shifts the oxidation potential of hydroxychloroquine with the formation of a single very intense peak at the position of Epa = 0.5 V/(vs Ag/AgCl) with a shift is ΔEp = 0.1 V(vs Ag/AgCl) compared to the unmodified electrode. The obtained ZnO@CPE hybrid nanocomposite was characterized by different techniques and showed excellent electrocatalytic activity and higher active surface area compared to the bare carbon paste electrode. Under the optimized experimental conditions, the ZnO@CPE sensor showed good analytical performance for the determination of trace amounts of hydroxychloroquine, a wide linearity range from 10(–3) M to 0.8 × 10(–6) M with a very low detection limit in the range of 1.33 × 10(–7) M, satisfactory selectivity, acceptable repeatability and reproducibility. The calculated recovery and coefficient of variation for the two samples analyzed are very satisfactory, ranging from 97.6 to 102% and 1.2 to 2.3% respectively. The proposed applied method and the fabricated sensor offer the possibility to analyze traces of hydroxychloroquine in real human urine and water samples. GRAPHICAL ABSTRACT: Strategy for the electro-oxidation reaction of hydroxychloroquine on the electro-catalytic surface of the ZnO@Carbon graphite electrode and real-time detection of hydroxychloroquine. [Image: see text]
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spelling pubmed-98250872023-01-09 Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine Zoubir, Jallal Bakas, Idriss Qourzal, Samir Tamimi, Malika Assabbane, Ali J Appl Electrochem Research Article ABSTRACT: In December 2019, the world experienced a new coronavirus, SARS-CoV-2, causing coronavirus disease 2019 originating from Wuhan.The virus has crossed national borders and now affects more than 200 countries and territories. Hydroxychloroquine has been considered as a drug capable of treating COVID-19. The objective of this work is to establish a simple platform for electrocatalytic detection of hydroxychloroquine in human urine samples and pharmaceutical samples (tablets) using a ZnO@CPE sensor constructed by simple and inexpensive hydrothermal methods using a square wave voltammetry method. The best results are obtained in a PBS electrolyte with irreversible behavior of the hydroxychloroquine complement and controlled by diffusion coupled with absorption phenomena. The ZnO@CPE shifts the oxidation potential of hydroxychloroquine with the formation of a single very intense peak at the position of Epa = 0.5 V/(vs Ag/AgCl) with a shift is ΔEp = 0.1 V(vs Ag/AgCl) compared to the unmodified electrode. The obtained ZnO@CPE hybrid nanocomposite was characterized by different techniques and showed excellent electrocatalytic activity and higher active surface area compared to the bare carbon paste electrode. Under the optimized experimental conditions, the ZnO@CPE sensor showed good analytical performance for the determination of trace amounts of hydroxychloroquine, a wide linearity range from 10(–3) M to 0.8 × 10(–6) M with a very low detection limit in the range of 1.33 × 10(–7) M, satisfactory selectivity, acceptable repeatability and reproducibility. The calculated recovery and coefficient of variation for the two samples analyzed are very satisfactory, ranging from 97.6 to 102% and 1.2 to 2.3% respectively. The proposed applied method and the fabricated sensor offer the possibility to analyze traces of hydroxychloroquine in real human urine and water samples. GRAPHICAL ABSTRACT: Strategy for the electro-oxidation reaction of hydroxychloroquine on the electro-catalytic surface of the ZnO@Carbon graphite electrode and real-time detection of hydroxychloroquine. [Image: see text] Springer Netherlands 2023-01-07 2023 /pmc/articles/PMC9825087/ /pubmed/36644408 http://dx.doi.org/10.1007/s10800-022-01835-2 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Article
Zoubir, Jallal
Bakas, Idriss
Qourzal, Samir
Tamimi, Malika
Assabbane, Ali
Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine
title Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine
title_full Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine
title_fullStr Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine
title_full_unstemmed Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine
title_short Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine
title_sort electrochemical sensor based on a zno-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. application: tap water and human urine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825087/
https://www.ncbi.nlm.nih.gov/pubmed/36644408
http://dx.doi.org/10.1007/s10800-022-01835-2
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