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Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes

BACKGROUND: Recent seminal studies have revealed that endosomal reactive oxygen species (ROS) promote rather than inhibit viral infection. Some ROS generators, including shikonin and H(2)O(2), have the potential to enhance recombinant adeno-associated virus (rAAV) transduction. However, the impact o...

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Detalles Bibliográficos
Autores principales:	Huang, Xiaoping, Wang, Xiao, Ren, Yanxuan, Gao, Pingzhang, Xu, Wentao, Xie, Xiaolan, Diao, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825130/ https://www.ncbi.nlm.nih.gov/pubmed/36611172 http://dx.doi.org/10.1186/s12985-023-01964-w

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