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Manipulation of topoisomerase expression inhibits cell division but not growth and reveals a distinctive promoter structure in Synechocystis

In cyanobacteria DNA supercoiling varies over the diurnal cycle and is integrated with temporal programs of transcription and replication. We manipulated DNA supercoiling in Synechocystis sp. PCC 6803 by CRISPRi-based knockdown of gyrase subunits and overexpression of topoisomerase I (TopoI). Cell d...

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Detalles Bibliográficos
Autores principales:	Behle, Anna, Dietsch, Maximilian, Goldschmidt, Louis, Murugathas, Wandana, Berwanger, Lutz C, Burmester, Jonas, Yao, Lun, Brandt, David, Busche, Tobias, Kalinowski, Jörn, Hudson, Elton P, Ebenhöh, Oliver, Axmann, Ilka M, Machné, Rainer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825172/ https://www.ncbi.nlm.nih.gov/pubmed/36533444 http://dx.doi.org/10.1093/nar/gkac1132

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