RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation

Aggregation of the microtubule-associated protein tau characterizes tauopathies, including Alzheimer's disease and frontotemporal lobar degeneration (FTLD-Tau). Gene expression regulation of tau is complex and incompletely understood. Here we report that the human tau gene (MAPT) generates two...

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Detalles Bibliográficos
Autores principales: Welden, Justin Ralph, Margvelani, Giorgi, Arizaca Maquera, Karol Andrea, Gudlavalleti, Bhavani, Miranda Sardón, Sandra C, Campos, Alexandre Rosa, Robil, Noémie, Lee, Daniel C, Hernandez, Alvaro G, Wang, Wang-Xia, Di, Jing, de la Grange, Pierre, Nelson, Peter T, Stamm, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825173/
https://www.ncbi.nlm.nih.gov/pubmed/36533443
http://dx.doi.org/10.1093/nar/gkac1129

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