Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding

Heterochromatin protein 1α (HP1α) is a crucial element of chromatin organization. It has been proposed that HP1α functions through liquid-liquid phase separation (LLPS), which allows it to compact chromatin into transcriptionally repressed heterochromatin regions. In vitro, HP1α can undergo phase se...

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Detalles Bibliográficos
Autores principales: Her, Cheenou, Phan, Tien M, Jovic, Nina, Kapoor, Utkarsh, Ackermann, Bryce E, Rizuan, Azamat, Kim, Young C, Mittal, Jeetain, Debelouchina, Galia T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825191/
https://www.ncbi.nlm.nih.gov/pubmed/36537242
http://dx.doi.org/10.1093/nar/gkac1194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825191/
https://www.ncbi.nlm.nih.gov/pubmed/36537242
http://dx.doi.org/10.1093/nar/gkac1194

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