Cargando…

Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding

Heterochromatin protein 1α (HP1α) is a crucial element of chromatin organization. It has been proposed that HP1α functions through liquid-liquid phase separation (LLPS), which allows it to compact chromatin into transcriptionally repressed heterochromatin regions. In vitro, HP1α can undergo phase se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Her, Cheenou, Phan, Tien M, Jovic, Nina, Kapoor, Utkarsh, Ackermann, Bryce E, Rizuan, Azamat, Kim, Young C, Mittal, Jeetain, Debelouchina, Galia T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825191/ https://www.ncbi.nlm.nih.gov/pubmed/36537242 http://dx.doi.org/10.1093/nar/gkac1194

Ejemplares similares

Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization
por: Phan, Tien M., et al.
Publicado: (2023)

Phosphorylated HP1α–Nucleosome Interactions in Phase Separated Environments
por: Elathram, Nesreen, et al.
Publicado: (2023)

Automethylation of G9a and its implication in wider substrate specificity and HP1 binding
por: Chin, Hang Gyeong, et al.
Publicado: (2007)

Triggering nucleic acid nanostructure assembly by conditional kissing interactions
por: Azéma, Laurent, et al.
Publicado: (2018)

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid
por: Hajjar, Mohammad, et al.
Publicado: (2022)

Recognition of single-stranded nucleic acids by small-molecule splicing modulators
por: Tang, Zhichao, et al.
Publicado: (2021)

Stability and mechanism of threose nucleic acid toward acid-mediated degradation
por: Lee, Erica M, et al.
Publicado: (2023)

Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids
por: Onizuka, Kazumitsu, et al.
Publicado: (2019)

Nucleoside analogs to manage sequence divergence in nucleic acid amplification and SNP detection
por: Yang, Zunyi, et al.
Publicado: (2018)

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids
por: Yang, Hui, et al.
Publicado: (2023)

‘Modulation of the enzymatic activities of replicative helicase (DnaB) by interaction with Hp0897: a possible mechanism for helicase loading in Helicobacter pylori’
por: Verma, Vijay, et al.
Publicado: (2016)

Components of variance in transcriptomics based on electrophoretic separation of cDNA fragments (cDNA-AFLP)
por: Weiberg, Arne, et al.
Publicado: (2009)

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
por: Gaus, Hans J, et al.
Publicado: (2019)

Cavity hairpin ThT-light nucleic acid switches: the construction of label- and enzyme-free sensing and imaging platforms
por: Lan, Xinyue, et al.
Publicado: (2023)

The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes
por: Prisecaru, Andreea, et al.
Publicado: (2014)

Incorporating uracil and 5-halouracils into short peptide nucleic acids for enhanced recognition of A–U pairs in dsRNAs
por: Patil, Kiran M, et al.
Publicado: (2018)

Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event
por: Okafor, C. Denise, et al.
Publicado: (2017)

Multiple nucleic acid cleavage modes in divergent type III CRISPR systems
por: Zhang, Jing, et al.
Publicado: (2016)

Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
por: Geny, Sylvain, et al.
Publicado: (2016)

Cationic porphyrins with large side arm substituents as resonance light scattering ratiometric probes for specific recognition of nucleic acid G-quadruplexes
por: Zhang, Li-Ming, et al.
Publicado: (2019)

Polymerization and nucleic acid-binding properties of human L1 ORF1 protein
por: Callahan, Kathryn E., et al.
Publicado: (2012)

Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain
por: Shastry, Shankar, et al.
Publicado: (2018)

Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids
por: Yamaguchi, Takao, et al.
Publicado: (2023)

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
por: Syed, Aleem, et al.
Publicado: (2023)

Site specific phosphorylation of yeast RNA polymerase I
por: Gerber, Jochen, et al.
Publicado: (2008)

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
por: Mukherjee, Sourav, et al.
Publicado: (2012)

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity
por: Seamon, Kyle J., et al.
Publicado: (2015)

Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3′-termini for initiating DNA synthesis
por: Oz-Gleenberg, Iris, et al.
Publicado: (2011)

Emerging Contributions of Solid-State NMR Spectroscopy to Chromatin Structural Biology
por: Ackermann, Bryce E., et al.
Publicado: (2021)

Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues
por: Xu, Liang, et al.
Publicado: (2014)

Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase
por: Imam, Syed Z., et al.
Publicado: (2007)

Acetylation and phosphorylation of human TFAM regulate TFAM–DNA interactions via contrasting mechanisms
por: King, Graeme A, et al.
Publicado: (2018)

Ball with hair: modular functionalization of highly stable G-quadruplex DNA nano-scaffolds through N2-guanine modification
por: Lech, Christopher Jacques, et al.
Publicado: (2017)

Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization
por: Tang, Xiaoli, et al.
Publicado: (2010)

Lewis acid catalysis of phosphoryl transfer from a copper(II)-NTP complex in a kinase ribozyme
por: Biondi, Elisa, et al.
Publicado: (2013)

Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity
por: Grozav, Adrian G., et al.
Publicado: (2009)

Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
por: Réblová, Kamila, et al.
Publicado: (2007)

RNA pseudoknots
por: Westhof, Eric, et al.
Publicado: (1992)

Isometric artifacts from polymerase chain reaction‐massively parallel sequencing analysis of short tandem repeat loci: An emerging issue from a new technology?
por: Zupanič Pajnič, Irena, et al.
Publicado: (2022)

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics
por: Orris, Benjamin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a1e3hs780bhnjjdcu33m6a4cr7