CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing

Disruptive mutations in the chromodomain helicase DNA-binding protein 8 gene (CHD8) have been recurrently associated with autism spectrum disorders (ASDs). Here we investigated how chromatin reacts to CHD8 suppression by analyzing a panel of histone modifications in induced pluripotent stem cell-der...

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Detalles Bibliográficos
Autores principales: Kerschbamer, Emanuela, Arnoldi, Michele, Tripathi, Takshashila, Pellegrini, Miguel, Maturi, Samuele, Erdin, Serkan, Salviato, Elisa, Di Leva, Francesca, Sebestyén, Endre, Dassi, Erik, Zarantonello, Giulia, Benelli, Matteo, Campos, Eric, Basson, M Albert, Gusella, James F, Gustincich, Stefano, Piazza, Silvano, Demichelis, Francesca, Talkowski, Michael E, Ferrari, Francesco, Biagioli, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825192/
https://www.ncbi.nlm.nih.gov/pubmed/36537238
http://dx.doi.org/10.1093/nar/gkac1134

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