Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development

Mutations in Bone Morphogenetic Protein (BMP) Receptor (BMPR)1A and SMAD4 are detected in 50% of juvenile polyposis syndrome (JPS) patients, who develop stroma-rich hamartomatous polyps. The established role of stromal cells in regulating BMP activity in the intestine implies a role for stromal cell...

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Detalles Bibliográficos
Autores principales: Ouahoud, Sarah, Westendorp, Barbara Florien, Voorneveld, Philip Willen, Abudukelimu, Subinuer, Koelink, Pim Johan, Pascual Garcia, Elena, Buuren, Jessica Flora Isabella, Harryvan, Tom Jacob, Lenos, Kristiaan Jan, van Wezel, Tom, Offerhaus, Johan Arnold, Fariña-Sarasqueta, Arantza, Crobach, Stijn, Slingerland, Marije, Hardwick, James Christopher Henry, Hawinkels, Lukas Jacobus Antonius Christiaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article—Alimentary Tract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825358/
https://www.ncbi.nlm.nih.gov/pubmed/36326956
http://dx.doi.org/10.1007/s00535-022-01928-x

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