Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development

Myb-like SWIRM and MPN domains 1 (MYSM1) is a chromatin binding protein with deubiquitinase (DUB) catalytic activity. Rare MYSM1 mutations in human patients result in an inherited bone marrow failure syndrome, highlighting the biomedical significance of MYSM1 in the hematopoietic system. We and othe...

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Detalles Bibliográficos
Autores principales: Liang, Yue, Bhatt, Garvit, Tung, Lin Tze, Wang, HanChen, Kim, Joo Eun, Mousa, Marwah, Plackoska, Viktoria, Illes, Katalin, Georges, Anna A., Gros, Philippe, Henneman, Linda, Huijbers, Ivo J., Nagar, Bhushan, Nijnik, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825392/
https://www.ncbi.nlm.nih.gov/pubmed/36611064
http://dx.doi.org/10.1038/s41598-023-27486-7

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