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ABC portal: a single-cell database and web server for blood cells
ABC portal (http://abc.sklehabc.com) is a database and web portal containing 198 single-cell transcriptomic datasets of development, differentiation and disorder of blood/immune cells. All the datasets were re-annotated with a manually curated and unified single-cell reference, especially for the ha...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825444/ https://www.ncbi.nlm.nih.gov/pubmed/35920330 http://dx.doi.org/10.1093/nar/gkac646 |
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author | Gao, Xin Hong, Fang Hu, Zhenyu Zhang, Zilong Lei, Yang Li, Xiaoyun Cheng, Tao |
author_facet | Gao, Xin Hong, Fang Hu, Zhenyu Zhang, Zilong Lei, Yang Li, Xiaoyun Cheng, Tao |
author_sort | Gao, Xin |
collection | PubMed |
description | ABC portal (http://abc.sklehabc.com) is a database and web portal containing 198 single-cell transcriptomic datasets of development, differentiation and disorder of blood/immune cells. All the datasets were re-annotated with a manually curated and unified single-cell reference, especially for the haematopoietic stem and progenitor cells. ABC portal provides web-based interactive analysis modules, especially a comprehensive cell-cell communication analysis and disease-related gene signature analysis. Importantly, ABC portal allows customized sample selection based on a combination of several metadata for downstream analysis and comparison analysis across datasets. ABC portal also allows users to select multiple cell types for analysis in the modules. Together, ABC portal provides an interactive interface of single-cell data exploration and re-analysis with customized analysis modules for the researchers and clinicians, and will facilitate understanding of haematopoiesis and blood/immune disorders. |
format | Online Article Text |
id | pubmed-9825444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98254442023-01-10 ABC portal: a single-cell database and web server for blood cells Gao, Xin Hong, Fang Hu, Zhenyu Zhang, Zilong Lei, Yang Li, Xiaoyun Cheng, Tao Nucleic Acids Res Database Issue ABC portal (http://abc.sklehabc.com) is a database and web portal containing 198 single-cell transcriptomic datasets of development, differentiation and disorder of blood/immune cells. All the datasets were re-annotated with a manually curated and unified single-cell reference, especially for the haematopoietic stem and progenitor cells. ABC portal provides web-based interactive analysis modules, especially a comprehensive cell-cell communication analysis and disease-related gene signature analysis. Importantly, ABC portal allows customized sample selection based on a combination of several metadata for downstream analysis and comparison analysis across datasets. ABC portal also allows users to select multiple cell types for analysis in the modules. Together, ABC portal provides an interactive interface of single-cell data exploration and re-analysis with customized analysis modules for the researchers and clinicians, and will facilitate understanding of haematopoiesis and blood/immune disorders. Oxford University Press 2022-08-03 /pmc/articles/PMC9825444/ /pubmed/35920330 http://dx.doi.org/10.1093/nar/gkac646 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Database Issue Gao, Xin Hong, Fang Hu, Zhenyu Zhang, Zilong Lei, Yang Li, Xiaoyun Cheng, Tao ABC portal: a single-cell database and web server for blood cells |
title | ABC portal: a single-cell database and web server for blood cells |
title_full | ABC portal: a single-cell database and web server for blood cells |
title_fullStr | ABC portal: a single-cell database and web server for blood cells |
title_full_unstemmed | ABC portal: a single-cell database and web server for blood cells |
title_short | ABC portal: a single-cell database and web server for blood cells |
title_sort | abc portal: a single-cell database and web server for blood cells |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825444/ https://www.ncbi.nlm.nih.gov/pubmed/35920330 http://dx.doi.org/10.1093/nar/gkac646 |
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