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ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers

Alternative splicing (AS) is a fundamental process that governs almost all aspects of cellular functions, and dysregulation in this process has been implicated in tumor initiation, progression and treatment resistance. With accumulating studies of carcinogenic mis-splicing in cancers, there is an ur...

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Autores principales: Wu, Song, Huang, Yue, Zhang, Mochen, Gong, Zheng, Wang, Guoliang, Zheng, Xinchang, Zong, Wenting, Zhao, Wei, Xing, Peiqi, Li, Rujiao, Liu, Zhaoqi, Bao, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825479/
https://www.ncbi.nlm.nih.gov/pubmed/36318242
http://dx.doi.org/10.1093/nar/gkac955
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author Wu, Song
Huang, Yue
Zhang, Mochen
Gong, Zheng
Wang, Guoliang
Zheng, Xinchang
Zong, Wenting
Zhao, Wei
Xing, Peiqi
Li, Rujiao
Liu, Zhaoqi
Bao, Yiming
author_facet Wu, Song
Huang, Yue
Zhang, Mochen
Gong, Zheng
Wang, Guoliang
Zheng, Xinchang
Zong, Wenting
Zhao, Wei
Xing, Peiqi
Li, Rujiao
Liu, Zhaoqi
Bao, Yiming
author_sort Wu, Song
collection PubMed
description Alternative splicing (AS) is a fundamental process that governs almost all aspects of cellular functions, and dysregulation in this process has been implicated in tumor initiation, progression and treatment resistance. With accumulating studies of carcinogenic mis-splicing in cancers, there is an urgent demand to integrate cancer-associated splicing changes to better understand their internal cross-talks and functional consequences from a global view. However, a resource of key functional AS events in human cancers is still lacking. To fill the gap, we developed ASCancer Atlas (https://ngdc.cncb.ac.cn/ascancer), a comprehensive knowledgebase of aberrant splicing in human cancers. Compared to extant databases, ASCancer Atlas features a high-confidence collection of 2006 cancer-associated splicing events experimentally proved to promote tumorigenesis, a systematic splicing regulatory network, and a suit of multi-scale online analysis tools. For each event, we manually curated the functional axis including upstream splicing regulators, splicing event annotations, downstream oncogenic effects, and possible therapeutic strategies. ASCancer Atlas also houses about 2 million computationally putative splicing events. Additionally, a user-friendly web interface was built to enable users to easily browse, search, visualize, analyze, and download all splicing events. Overall, ASCancer Atlas provides a unique resource to study the functional roles of splicing dysregulation in human cancers.
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spelling pubmed-98254792023-01-10 ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers Wu, Song Huang, Yue Zhang, Mochen Gong, Zheng Wang, Guoliang Zheng, Xinchang Zong, Wenting Zhao, Wei Xing, Peiqi Li, Rujiao Liu, Zhaoqi Bao, Yiming Nucleic Acids Res Database Issue Alternative splicing (AS) is a fundamental process that governs almost all aspects of cellular functions, and dysregulation in this process has been implicated in tumor initiation, progression and treatment resistance. With accumulating studies of carcinogenic mis-splicing in cancers, there is an urgent demand to integrate cancer-associated splicing changes to better understand their internal cross-talks and functional consequences from a global view. However, a resource of key functional AS events in human cancers is still lacking. To fill the gap, we developed ASCancer Atlas (https://ngdc.cncb.ac.cn/ascancer), a comprehensive knowledgebase of aberrant splicing in human cancers. Compared to extant databases, ASCancer Atlas features a high-confidence collection of 2006 cancer-associated splicing events experimentally proved to promote tumorigenesis, a systematic splicing regulatory network, and a suit of multi-scale online analysis tools. For each event, we manually curated the functional axis including upstream splicing regulators, splicing event annotations, downstream oncogenic effects, and possible therapeutic strategies. ASCancer Atlas also houses about 2 million computationally putative splicing events. Additionally, a user-friendly web interface was built to enable users to easily browse, search, visualize, analyze, and download all splicing events. Overall, ASCancer Atlas provides a unique resource to study the functional roles of splicing dysregulation in human cancers. Oxford University Press 2022-11-01 /pmc/articles/PMC9825479/ /pubmed/36318242 http://dx.doi.org/10.1093/nar/gkac955 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Issue
Wu, Song
Huang, Yue
Zhang, Mochen
Gong, Zheng
Wang, Guoliang
Zheng, Xinchang
Zong, Wenting
Zhao, Wei
Xing, Peiqi
Li, Rujiao
Liu, Zhaoqi
Bao, Yiming
ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers
title ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers
title_full ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers
title_fullStr ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers
title_full_unstemmed ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers
title_short ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers
title_sort ascancer atlas: a comprehensive knowledgebase of alternative splicing in human cancers
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825479/
https://www.ncbi.nlm.nih.gov/pubmed/36318242
http://dx.doi.org/10.1093/nar/gkac955
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