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EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes

We present an update of EpiFactors, a manually curated database providing information about epigenetic regulators, their complexes, targets, and products which is openly accessible at http://epifactors.autosome.org. An updated version of the EpiFactors contains information on 902 proteins, including...

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Autores principales: Marakulina, Daria, Vorontsov, Ilya E, Kulakovskiy, Ivan V, Lennartsson, Andreas, Drabløs, Finn, Medvedeva, Yulia A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825597/
https://www.ncbi.nlm.nih.gov/pubmed/36350659
http://dx.doi.org/10.1093/nar/gkac989
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author Marakulina, Daria
Vorontsov, Ilya E
Kulakovskiy, Ivan V
Lennartsson, Andreas
Drabløs, Finn
Medvedeva, Yulia A
author_facet Marakulina, Daria
Vorontsov, Ilya E
Kulakovskiy, Ivan V
Lennartsson, Andreas
Drabløs, Finn
Medvedeva, Yulia A
author_sort Marakulina, Daria
collection PubMed
description We present an update of EpiFactors, a manually curated database providing information about epigenetic regulators, their complexes, targets, and products which is openly accessible at http://epifactors.autosome.org. An updated version of the EpiFactors contains information on 902 proteins, including 101 histones and protamines, and, as a main update, a newly curated collection of 124 lncRNAs involved in epigenetic regulation. The amount of publications concerning the role of lncRNA in epigenetics is rapidly growing. Yet, the resource that compiles, integrates, organizes, and presents curated information on lncRNAs in epigenetics is missing. EpiFactors fills this gap and provides data on epigenetic regulators in an accessible and user-friendly form. For 820 of the genes in EpiFactors, we include expression estimates across multiple cell types assessed by CAGE-Seq in the FANTOM5 project. In addition, the updated EpiFactors contains information on 73 protein complexes involved in epigenetic regulation. Our resource is practical for a wide range of users, including biologists, bioinformaticians and molecular/systems biologists.
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spelling pubmed-98255972023-01-10 EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes Marakulina, Daria Vorontsov, Ilya E Kulakovskiy, Ivan V Lennartsson, Andreas Drabløs, Finn Medvedeva, Yulia A Nucleic Acids Res Database Issue We present an update of EpiFactors, a manually curated database providing information about epigenetic regulators, their complexes, targets, and products which is openly accessible at http://epifactors.autosome.org. An updated version of the EpiFactors contains information on 902 proteins, including 101 histones and protamines, and, as a main update, a newly curated collection of 124 lncRNAs involved in epigenetic regulation. The amount of publications concerning the role of lncRNA in epigenetics is rapidly growing. Yet, the resource that compiles, integrates, organizes, and presents curated information on lncRNAs in epigenetics is missing. EpiFactors fills this gap and provides data on epigenetic regulators in an accessible and user-friendly form. For 820 of the genes in EpiFactors, we include expression estimates across multiple cell types assessed by CAGE-Seq in the FANTOM5 project. In addition, the updated EpiFactors contains information on 73 protein complexes involved in epigenetic regulation. Our resource is practical for a wide range of users, including biologists, bioinformaticians and molecular/systems biologists. Oxford University Press 2022-11-09 /pmc/articles/PMC9825597/ /pubmed/36350659 http://dx.doi.org/10.1093/nar/gkac989 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Database Issue
Marakulina, Daria
Vorontsov, Ilya E
Kulakovskiy, Ivan V
Lennartsson, Andreas
Drabløs, Finn
Medvedeva, Yulia A
EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
title EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
title_full EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
title_fullStr EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
title_full_unstemmed EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
title_short EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
title_sort epifactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825597/
https://www.ncbi.nlm.nih.gov/pubmed/36350659
http://dx.doi.org/10.1093/nar/gkac989
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