Evolution of Nrf2 Gene Expression in HIT-T15 β-Cells During Chronic Oxidative Stress and Glucose Toxicity

CONTEXT: Chronic exposure of pancreatic islets to elevated glucose levels causes progressive declines in beta cell Pdx-1 and insulin gene expression, and glucose-induced insulin secretion. This has been shown to be associated with excessive islet reactive oxygen species and consequent damage to beta...

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Detalles Bibliográficos
Autores principales: Abebe, Tsehay, Bogachus, Lindsey, Vegaraju, Adithya Krishna, Robertson, R Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825721/
https://www.ncbi.nlm.nih.gov/pubmed/36632484
http://dx.doi.org/10.1210/jendso/bvac178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825721/
https://www.ncbi.nlm.nih.gov/pubmed/36632484
http://dx.doi.org/10.1210/jendso/bvac178

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