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First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature

BACKGROUND AND PURPOSE: Invasive mucormycosis is a rare mycosis that affects most cases of uncontrolled diabetes and has a high mortality rate. Patients with COVID-19 are at high risk of developing invasive mucormycosis due to the consumption of anti-inflammatory drugs such as corticosteroids and de...

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Autores principales: Taghizadeh Armaki, Mojtaba, Jafarzadeh, Jalal, Mahdavi Omran, Saeid, Bayani, Masoumeh, Tavassoli, Ali, Faeli, Leila, Nosratabadi, Mohsen, Yaalimadad, Sanaz, Nikoueian, Bahador, Haghani, Iman, Moazeni, Maryam, Shokohi, Tahereh, Taghi Hedayati, Mohammad, Abastabar, Mahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Medical Mycology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825793/
https://www.ncbi.nlm.nih.gov/pubmed/36654791
http://dx.doi.org/10.18502/cmm.8.2.10333
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author Taghizadeh Armaki, Mojtaba
Jafarzadeh, Jalal
Mahdavi Omran, Saeid
Bayani, Masoumeh
Tavassoli, Ali
Faeli, Leila
Nosratabadi, Mohsen
Yaalimadad, Sanaz
Nikoueian, Bahador
Haghani, Iman
Moazeni, Maryam
Shokohi, Tahereh
Taghi Hedayati, Mohammad
Abastabar, Mahdi
author_facet Taghizadeh Armaki, Mojtaba
Jafarzadeh, Jalal
Mahdavi Omran, Saeid
Bayani, Masoumeh
Tavassoli, Ali
Faeli, Leila
Nosratabadi, Mohsen
Yaalimadad, Sanaz
Nikoueian, Bahador
Haghani, Iman
Moazeni, Maryam
Shokohi, Tahereh
Taghi Hedayati, Mohammad
Abastabar, Mahdi
author_sort Taghizadeh Armaki, Mojtaba
collection PubMed
description BACKGROUND AND PURPOSE: Invasive mucormycosis is a rare mycosis that affects most cases of uncontrolled diabetes and has a high mortality rate. Patients with COVID-19 are at high risk of developing invasive mucormycosis due to the consumption of anti-inflammatory drugs such as corticosteroids and dexamethasone. Rhizopus species followed by Rhizomucor spp. and Mucor spp. are the main common etiological agents of rhino-orbital mucormycosis. Therefore, this study aimed to present a case of mucormycosis due to Syncephalastrum racemosum in a diabetic patient with COVID-19 for the first time in Iran. CASE REPORT: A 73-year-old diabetic female was referred to Ayatollah Rouhani Hospital in Babol, Iran, with a confirmed COVID-19 diagnosis, based on positive RT-PCR and computed tomography of the lungs. She has received methylprednisolone due to severe lung complications. Nasal involvement and left orbital swelling were observed 20 days after the hospitalization. By sinus endoscopic surgery, debridement was done and histopathology indicated wide hyphae (without septa). The sequenced PCR products displayed Syncephalastrum racemosum. In the antifungal susceptibility test, amphotericin B showed good activity against S. racemosum and the patient survived with timely treatment. CONCLUSION: This is the first case report of rhino-orbital mucormycosis due to S. racemosum in COVID-19 patient; therefore, S. racemosum can be considered one of the etiological factors of rhino-orbital mucormycosis in COVID-19 cases.
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spelling pubmed-98257932023-01-17 First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature Taghizadeh Armaki, Mojtaba Jafarzadeh, Jalal Mahdavi Omran, Saeid Bayani, Masoumeh Tavassoli, Ali Faeli, Leila Nosratabadi, Mohsen Yaalimadad, Sanaz Nikoueian, Bahador Haghani, Iman Moazeni, Maryam Shokohi, Tahereh Taghi Hedayati, Mohammad Abastabar, Mahdi Curr Med Mycol Case Report BACKGROUND AND PURPOSE: Invasive mucormycosis is a rare mycosis that affects most cases of uncontrolled diabetes and has a high mortality rate. Patients with COVID-19 are at high risk of developing invasive mucormycosis due to the consumption of anti-inflammatory drugs such as corticosteroids and dexamethasone. Rhizopus species followed by Rhizomucor spp. and Mucor spp. are the main common etiological agents of rhino-orbital mucormycosis. Therefore, this study aimed to present a case of mucormycosis due to Syncephalastrum racemosum in a diabetic patient with COVID-19 for the first time in Iran. CASE REPORT: A 73-year-old diabetic female was referred to Ayatollah Rouhani Hospital in Babol, Iran, with a confirmed COVID-19 diagnosis, based on positive RT-PCR and computed tomography of the lungs. She has received methylprednisolone due to severe lung complications. Nasal involvement and left orbital swelling were observed 20 days after the hospitalization. By sinus endoscopic surgery, debridement was done and histopathology indicated wide hyphae (without septa). The sequenced PCR products displayed Syncephalastrum racemosum. In the antifungal susceptibility test, amphotericin B showed good activity against S. racemosum and the patient survived with timely treatment. CONCLUSION: This is the first case report of rhino-orbital mucormycosis due to S. racemosum in COVID-19 patient; therefore, S. racemosum can be considered one of the etiological factors of rhino-orbital mucormycosis in COVID-19 cases. Iranian Society of Medical Mycology 2022-06 /pmc/articles/PMC9825793/ /pubmed/36654791 http://dx.doi.org/10.18502/cmm.8.2.10333 Text en Copyright: © 2021, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY) License ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted use, distribution and reproduction in any medium, provided appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Taghizadeh Armaki, Mojtaba
Jafarzadeh, Jalal
Mahdavi Omran, Saeid
Bayani, Masoumeh
Tavassoli, Ali
Faeli, Leila
Nosratabadi, Mohsen
Yaalimadad, Sanaz
Nikoueian, Bahador
Haghani, Iman
Moazeni, Maryam
Shokohi, Tahereh
Taghi Hedayati, Mohammad
Abastabar, Mahdi
First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature
title First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature
title_full First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature
title_fullStr First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature
title_full_unstemmed First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature
title_short First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-19 in Iran and review of recent literature
title_sort first report of rhino-orbital mucormycosis caused by syncephalastrum racemosum in a diabetic patient with covid-19 in iran and review of recent literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825793/
https://www.ncbi.nlm.nih.gov/pubmed/36654791
http://dx.doi.org/10.18502/cmm.8.2.10333
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