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Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with re...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825926/ https://www.ncbi.nlm.nih.gov/pubmed/36004608 http://dx.doi.org/10.1111/ejn.15806 |
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author | Roddy, Darren William Roman, Elena Nasa, Anurag Gazzaz, Areej Zainy, Ahmed Burke, Tom Staines, Lorna Kelleher, Ian O'Neill, Aisling Clarke, Mary O'Hanlon, Erik Cannon, Mary |
author_facet | Roddy, Darren William Roman, Elena Nasa, Anurag Gazzaz, Areej Zainy, Ahmed Burke, Tom Staines, Lorna Kelleher, Ian O'Neill, Aisling Clarke, Mary O'Hanlon, Erik Cannon, Mary |
author_sort | Roddy, Darren William |
collection | PubMed |
description | Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with reported PEs and matched controls, we examined the cingulum white matter tract along its length rather than as the usually reported single indivisible structure. Complex regional differences in diffusion metrics were found along the bundle at key loci following Bonferroni significance adjustment (p < .00013) with moderate to large effect sizes (.11–.76) throughout all significant subsegments. In this prospective community‐based cohort of school‐age children, these findings suggest that white matter alterations in the limbic system may be more common in the general non‐clinical adolescent population than previously thought. Such white matter alternations may only be uncovered using a similar more granular along‐tract analysis of white matter tracts. |
format | Online Article Text |
id | pubmed-9825926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98259262023-01-09 Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis Roddy, Darren William Roman, Elena Nasa, Anurag Gazzaz, Areej Zainy, Ahmed Burke, Tom Staines, Lorna Kelleher, Ian O'Neill, Aisling Clarke, Mary O'Hanlon, Erik Cannon, Mary Eur J Neurosci Clinical and Translational Neuroscience Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with reported PEs and matched controls, we examined the cingulum white matter tract along its length rather than as the usually reported single indivisible structure. Complex regional differences in diffusion metrics were found along the bundle at key loci following Bonferroni significance adjustment (p < .00013) with moderate to large effect sizes (.11–.76) throughout all significant subsegments. In this prospective community‐based cohort of school‐age children, these findings suggest that white matter alterations in the limbic system may be more common in the general non‐clinical adolescent population than previously thought. Such white matter alternations may only be uncovered using a similar more granular along‐tract analysis of white matter tracts. John Wiley and Sons Inc. 2022-09-12 2022-10 /pmc/articles/PMC9825926/ /pubmed/36004608 http://dx.doi.org/10.1111/ejn.15806 Text en © 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical and Translational Neuroscience Roddy, Darren William Roman, Elena Nasa, Anurag Gazzaz, Areej Zainy, Ahmed Burke, Tom Staines, Lorna Kelleher, Ian O'Neill, Aisling Clarke, Mary O'Hanlon, Erik Cannon, Mary Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis |
title | Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis |
title_full | Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis |
title_fullStr | Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis |
title_full_unstemmed | Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis |
title_short | Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis |
title_sort | microstructural changes along the cingulum in young adolescents with psychotic experiences: an along‐tract analysis |
topic | Clinical and Translational Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825926/ https://www.ncbi.nlm.nih.gov/pubmed/36004608 http://dx.doi.org/10.1111/ejn.15806 |
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