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Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis

Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with re...

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Autores principales: Roddy, Darren William, Roman, Elena, Nasa, Anurag, Gazzaz, Areej, Zainy, Ahmed, Burke, Tom, Staines, Lorna, Kelleher, Ian, O'Neill, Aisling, Clarke, Mary, O'Hanlon, Erik, Cannon, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825926/
https://www.ncbi.nlm.nih.gov/pubmed/36004608
http://dx.doi.org/10.1111/ejn.15806
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author Roddy, Darren William
Roman, Elena
Nasa, Anurag
Gazzaz, Areej
Zainy, Ahmed
Burke, Tom
Staines, Lorna
Kelleher, Ian
O'Neill, Aisling
Clarke, Mary
O'Hanlon, Erik
Cannon, Mary
author_facet Roddy, Darren William
Roman, Elena
Nasa, Anurag
Gazzaz, Areej
Zainy, Ahmed
Burke, Tom
Staines, Lorna
Kelleher, Ian
O'Neill, Aisling
Clarke, Mary
O'Hanlon, Erik
Cannon, Mary
author_sort Roddy, Darren William
collection PubMed
description Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with reported PEs and matched controls, we examined the cingulum white matter tract along its length rather than as the usually reported single indivisible structure. Complex regional differences in diffusion metrics were found along the bundle at key loci following Bonferroni significance adjustment (p < .00013) with moderate to large effect sizes (.11–.76) throughout all significant subsegments. In this prospective community‐based cohort of school‐age children, these findings suggest that white matter alterations in the limbic system may be more common in the general non‐clinical adolescent population than previously thought. Such white matter alternations may only be uncovered using a similar more granular along‐tract analysis of white matter tracts.
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spelling pubmed-98259262023-01-09 Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis Roddy, Darren William Roman, Elena Nasa, Anurag Gazzaz, Areej Zainy, Ahmed Burke, Tom Staines, Lorna Kelleher, Ian O'Neill, Aisling Clarke, Mary O'Hanlon, Erik Cannon, Mary Eur J Neurosci Clinical and Translational Neuroscience Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with reported PEs and matched controls, we examined the cingulum white matter tract along its length rather than as the usually reported single indivisible structure. Complex regional differences in diffusion metrics were found along the bundle at key loci following Bonferroni significance adjustment (p < .00013) with moderate to large effect sizes (.11–.76) throughout all significant subsegments. In this prospective community‐based cohort of school‐age children, these findings suggest that white matter alterations in the limbic system may be more common in the general non‐clinical adolescent population than previously thought. Such white matter alternations may only be uncovered using a similar more granular along‐tract analysis of white matter tracts. John Wiley and Sons Inc. 2022-09-12 2022-10 /pmc/articles/PMC9825926/ /pubmed/36004608 http://dx.doi.org/10.1111/ejn.15806 Text en © 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical and Translational Neuroscience
Roddy, Darren William
Roman, Elena
Nasa, Anurag
Gazzaz, Areej
Zainy, Ahmed
Burke, Tom
Staines, Lorna
Kelleher, Ian
O'Neill, Aisling
Clarke, Mary
O'Hanlon, Erik
Cannon, Mary
Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
title Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
title_full Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
title_fullStr Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
title_full_unstemmed Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
title_short Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
title_sort microstructural changes along the cingulum in young adolescents with psychotic experiences: an along‐tract analysis
topic Clinical and Translational Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825926/
https://www.ncbi.nlm.nih.gov/pubmed/36004608
http://dx.doi.org/10.1111/ejn.15806
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