Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate

A site‐specific method for the preparation of N‐glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag(I)‐promoted, site‐specific conversion to N‐glycosylated Asn residues in peptides.

Detalles Bibliográficos
Autores principales: Taresh, Ameer B., Hutton, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826000/
https://www.ncbi.nlm.nih.gov/pubmed/36068172
http://dx.doi.org/10.1002/anie.202210367
Descripción
Sumario:A site‐specific method for the preparation of N‐glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag(I)‐promoted, site‐specific conversion to N‐glycosylated Asn residues in peptides.

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