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Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate
A site‐specific method for the preparation of N‐glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag(I)‐promoted, site‐specific conversion to N‐glycosylated Asn residues in peptides.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826000/ https://www.ncbi.nlm.nih.gov/pubmed/36068172 http://dx.doi.org/10.1002/anie.202210367 |
| _version_ | 1784866747888697344 |
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| author | Taresh, Ameer B. Hutton, Craig A. |
| author_facet | Taresh, Ameer B. Hutton, Craig A. |
| author_sort | Taresh, Ameer B. |
| collection | PubMed |
| description | A site‐specific method for the preparation of N‐glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag(I)‐promoted, site‐specific conversion to N‐glycosylated Asn residues in peptides. |
| format | Online Article Text |
| id | pubmed-9826000 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98260002023-01-09 Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate Taresh, Ameer B. Hutton, Craig A. Angew Chem Int Ed Engl Communications A site‐specific method for the preparation of N‐glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag(I)‐promoted, site‐specific conversion to N‐glycosylated Asn residues in peptides. John Wiley and Sons Inc. 2022-09-21 2022-10-24 /pmc/articles/PMC9826000/ /pubmed/36068172 http://dx.doi.org/10.1002/anie.202210367 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Communications Taresh, Ameer B. Hutton, Craig A. Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate |
| title | Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate |
| title_full | Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate |
| title_fullStr | Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate |
| title_full_unstemmed | Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate |
| title_short | Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate |
| title_sort | site specific preparation of n‐glycosylated peptides: thioamide‐directed activation of aspartate |
| topic | Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826000/ https://www.ncbi.nlm.nih.gov/pubmed/36068172 http://dx.doi.org/10.1002/anie.202210367 |
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