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Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate
A site‐specific method for the preparation of N‐glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag(I)‐promoted, site‐specific conversion to N‐glycosylated Asn residues in peptides.
Autores principales: | Taresh, Ameer B., Hutton, Craig A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826000/ https://www.ncbi.nlm.nih.gov/pubmed/36068172 http://dx.doi.org/10.1002/anie.202210367 |
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