An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation

In this concise practitioner protocol, the radiochemical synthesis of 2′‐deoxy‐2′‐[(18)F]fluoro‐9‐β‐d‐arabinofuranosylguanine ([(18)F]FAraG) suitable for human positron emission tomography (PET) studies is described and the results from validation productions are presented. The high specific activit...

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Detalles Bibliográficos
Autores principales: Holt, Daniel P., Dannals, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Practitioner Protocol ‐ Synthesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826029/
https://www.ncbi.nlm.nih.gov/pubmed/36000273
http://dx.doi.org/10.1002/jlcr.3999
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author Holt, Daniel P.
Dannals, Robert F.
author_facet Holt, Daniel P.
Dannals, Robert F.
author_sort Holt, Daniel P.
collection PubMed
description In this concise practitioner protocol, the radiochemical synthesis of 2′‐deoxy‐2′‐[(18)F]fluoro‐9‐β‐d‐arabinofuranosylguanine ([(18)F]FAraG) suitable for human positron emission tomography (PET) studies is described and the results from validation productions are presented. The high specific activity (sometimes referred to as molar activity) radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements established by the U.S. Food and Drug Administration.
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spelling pubmed-98260292023-01-09 An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation Holt, Daniel P. Dannals, Robert F. J Labelled Comp Radiopharm Practitioner Protocol ‐ Synthesis In this concise practitioner protocol, the radiochemical synthesis of 2′‐deoxy‐2′‐[(18)F]fluoro‐9‐β‐d‐arabinofuranosylguanine ([(18)F]FAraG) suitable for human positron emission tomography (PET) studies is described and the results from validation productions are presented. The high specific activity (sometimes referred to as molar activity) radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements established by the U.S. Food and Drug Administration. John Wiley and Sons Inc. 2022-09-05 2022-10 /pmc/articles/PMC9826029/ /pubmed/36000273 http://dx.doi.org/10.1002/jlcr.3999 Text en © 2022 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Practitioner Protocol ‐ Synthesis
Holt, Daniel P.
Dannals, Robert F.
An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation
title An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation
title_full An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation
title_fullStr An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation
title_full_unstemmed An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation
title_short An improved radiosynthesis of [(18)F]FAraG, a PET radiotracer for imaging T‐cell activation
title_sort improved radiosynthesis of [(18)f]farag, a pet radiotracer for imaging t‐cell activation
topic Practitioner Protocol ‐ Synthesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826029/
https://www.ncbi.nlm.nih.gov/pubmed/36000273
http://dx.doi.org/10.1002/jlcr.3999
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