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A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers

Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogeni...

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Autores principales: Rea, Molly, Boto, Elena, Holmes, Niall, Hill, Ryan, Osborne, James, Rhodes, Natalie, Leggett, James, Rier, Lukas, Bowtell, Richard, Shah, Vishal, Brookes, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826099/
https://www.ncbi.nlm.nih.gov/pubmed/36065147
http://dx.doi.org/10.1111/nyas.14890
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author Rea, Molly
Boto, Elena
Holmes, Niall
Hill, Ryan
Osborne, James
Rhodes, Natalie
Leggett, James
Rier, Lukas
Bowtell, Richard
Shah, Vishal
Brookes, Matthew J.
author_facet Rea, Molly
Boto, Elena
Holmes, Niall
Hill, Ryan
Osborne, James
Rhodes, Natalie
Leggett, James
Rier, Lukas
Bowtell, Richard
Shah, Vishal
Brookes, Matthew J.
author_sort Rea, Molly
collection PubMed
description Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogenic field‐sensing technologies. In contrast, MEG using optically pumped magnetometers (OPM‐MEG) employs small, lightweight, noncryogenic sensors that provide data with higher sensitivity and spatial resolution, a natural scanning environment (including participant movement), and adaptability to any age. However, OPM‐MEG is new and the optimum way to design a system is unknown. Here, we construct a novel, 90‐channel triaxial OPM‐MEG system and use it to map motor function during a naturalistic handwriting task. Results show that high‐precision magnetic field control reduced background fields to ∼200 pT, enabling free participant movement. Our triaxial array offered twice the total measured signal and better interference rejection compared to a conventional (single‐axis) design. We mapped neural oscillatory activity to the sensorimotor network, demonstrating significant differences in motor network activity and connectivity for left‐handed versus right‐handed handwriting. Repeatability across scans showed that we can map electrophysiological activity with an accuracy ∼4 mm. Overall, our study introduces a novel triaxial OPM‐MEG design and confirms its potential for high‐performance functional neuroimaging.
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spelling pubmed-98260992023-01-09 A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers Rea, Molly Boto, Elena Holmes, Niall Hill, Ryan Osborne, James Rhodes, Natalie Leggett, James Rier, Lukas Bowtell, Richard Shah, Vishal Brookes, Matthew J. Ann N Y Acad Sci Original Articles Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogenic field‐sensing technologies. In contrast, MEG using optically pumped magnetometers (OPM‐MEG) employs small, lightweight, noncryogenic sensors that provide data with higher sensitivity and spatial resolution, a natural scanning environment (including participant movement), and adaptability to any age. However, OPM‐MEG is new and the optimum way to design a system is unknown. Here, we construct a novel, 90‐channel triaxial OPM‐MEG system and use it to map motor function during a naturalistic handwriting task. Results show that high‐precision magnetic field control reduced background fields to ∼200 pT, enabling free participant movement. Our triaxial array offered twice the total measured signal and better interference rejection compared to a conventional (single‐axis) design. We mapped neural oscillatory activity to the sensorimotor network, demonstrating significant differences in motor network activity and connectivity for left‐handed versus right‐handed handwriting. Repeatability across scans showed that we can map electrophysiological activity with an accuracy ∼4 mm. Overall, our study introduces a novel triaxial OPM‐MEG design and confirms its potential for high‐performance functional neuroimaging. John Wiley and Sons Inc. 2022-09-05 2022-11 /pmc/articles/PMC9826099/ /pubmed/36065147 http://dx.doi.org/10.1111/nyas.14890 Text en © 2022 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Rea, Molly
Boto, Elena
Holmes, Niall
Hill, Ryan
Osborne, James
Rhodes, Natalie
Leggett, James
Rier, Lukas
Bowtell, Richard
Shah, Vishal
Brookes, Matthew J.
A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
title A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
title_full A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
title_fullStr A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
title_full_unstemmed A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
title_short A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
title_sort 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826099/
https://www.ncbi.nlm.nih.gov/pubmed/36065147
http://dx.doi.org/10.1111/nyas.14890
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