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A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers
Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogeni...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826099/ https://www.ncbi.nlm.nih.gov/pubmed/36065147 http://dx.doi.org/10.1111/nyas.14890 |
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author | Rea, Molly Boto, Elena Holmes, Niall Hill, Ryan Osborne, James Rhodes, Natalie Leggett, James Rier, Lukas Bowtell, Richard Shah, Vishal Brookes, Matthew J. |
author_facet | Rea, Molly Boto, Elena Holmes, Niall Hill, Ryan Osborne, James Rhodes, Natalie Leggett, James Rier, Lukas Bowtell, Richard Shah, Vishal Brookes, Matthew J. |
author_sort | Rea, Molly |
collection | PubMed |
description | Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogenic field‐sensing technologies. In contrast, MEG using optically pumped magnetometers (OPM‐MEG) employs small, lightweight, noncryogenic sensors that provide data with higher sensitivity and spatial resolution, a natural scanning environment (including participant movement), and adaptability to any age. However, OPM‐MEG is new and the optimum way to design a system is unknown. Here, we construct a novel, 90‐channel triaxial OPM‐MEG system and use it to map motor function during a naturalistic handwriting task. Results show that high‐precision magnetic field control reduced background fields to ∼200 pT, enabling free participant movement. Our triaxial array offered twice the total measured signal and better interference rejection compared to a conventional (single‐axis) design. We mapped neural oscillatory activity to the sensorimotor network, demonstrating significant differences in motor network activity and connectivity for left‐handed versus right‐handed handwriting. Repeatability across scans showed that we can map electrophysiological activity with an accuracy ∼4 mm. Overall, our study introduces a novel triaxial OPM‐MEG design and confirms its potential for high‐performance functional neuroimaging. |
format | Online Article Text |
id | pubmed-9826099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98260992023-01-09 A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers Rea, Molly Boto, Elena Holmes, Niall Hill, Ryan Osborne, James Rhodes, Natalie Leggett, James Rier, Lukas Bowtell, Richard Shah, Vishal Brookes, Matthew J. Ann N Y Acad Sci Original Articles Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogenic field‐sensing technologies. In contrast, MEG using optically pumped magnetometers (OPM‐MEG) employs small, lightweight, noncryogenic sensors that provide data with higher sensitivity and spatial resolution, a natural scanning environment (including participant movement), and adaptability to any age. However, OPM‐MEG is new and the optimum way to design a system is unknown. Here, we construct a novel, 90‐channel triaxial OPM‐MEG system and use it to map motor function during a naturalistic handwriting task. Results show that high‐precision magnetic field control reduced background fields to ∼200 pT, enabling free participant movement. Our triaxial array offered twice the total measured signal and better interference rejection compared to a conventional (single‐axis) design. We mapped neural oscillatory activity to the sensorimotor network, demonstrating significant differences in motor network activity and connectivity for left‐handed versus right‐handed handwriting. Repeatability across scans showed that we can map electrophysiological activity with an accuracy ∼4 mm. Overall, our study introduces a novel triaxial OPM‐MEG design and confirms its potential for high‐performance functional neuroimaging. John Wiley and Sons Inc. 2022-09-05 2022-11 /pmc/articles/PMC9826099/ /pubmed/36065147 http://dx.doi.org/10.1111/nyas.14890 Text en © 2022 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Rea, Molly Boto, Elena Holmes, Niall Hill, Ryan Osborne, James Rhodes, Natalie Leggett, James Rier, Lukas Bowtell, Richard Shah, Vishal Brookes, Matthew J. A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers |
title | A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers |
title_full | A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers |
title_fullStr | A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers |
title_full_unstemmed | A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers |
title_short | A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers |
title_sort | 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826099/ https://www.ncbi.nlm.nih.gov/pubmed/36065147 http://dx.doi.org/10.1111/nyas.14890 |
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