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Antiretroviral drug–drug interactions: A comparison of online drug interaction databases
WHAT IS KNOWN AND OBJECTIVE: Antiretrovirals have a high drug interaction potential, which can lead to increased toxicity and/or decreased efficacy. Multiple databases are available to assess drug–drug interactions. The aim of our study was to compare interaction identification for commonly used ARV...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826109/ https://www.ncbi.nlm.nih.gov/pubmed/36059105 http://dx.doi.org/10.1111/jcpt.13750 |
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author | Drwiega, Emily N. Badowski, Melissa E. Michienzi, Sarah |
author_facet | Drwiega, Emily N. Badowski, Melissa E. Michienzi, Sarah |
author_sort | Drwiega, Emily N. |
collection | PubMed |
description | WHAT IS KNOWN AND OBJECTIVE: Antiretrovirals have a high drug interaction potential, which can lead to increased toxicity and/or decreased efficacy. Multiple databases are available to assess drug–drug interactions. The aim of our study was to compare interaction identification for commonly used ARVs and concomitant medications between six different online drug–drug interaction databases. COMMENT: This was a cross‐sectional review using each of the following six databases: LexiComp®, Clinical Pharmacology®, Micromedex®, Epocrates®, University of Liverpool, and University of Toronto. Sixteen antiretroviral drugs and 100 of the DrugStats Database “Top 200 of 2019” list of medications were included. Each of the six databases identified a different number of actual or potential interactions. The number of interactions ranged from 211 to 283. WHAT IS NEW AND CONCLUSIONS: A variety of databases exist with inconsistent identification of actual or potential drug–drug interactions amongst them. It may be beneficial to cross‐reference multiple databases prior to making decisions regarding patient care. |
format | Online Article Text |
id | pubmed-9826109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98261092023-01-09 Antiretroviral drug–drug interactions: A comparison of online drug interaction databases Drwiega, Emily N. Badowski, Melissa E. Michienzi, Sarah J Clin Pharm Ther Commentary WHAT IS KNOWN AND OBJECTIVE: Antiretrovirals have a high drug interaction potential, which can lead to increased toxicity and/or decreased efficacy. Multiple databases are available to assess drug–drug interactions. The aim of our study was to compare interaction identification for commonly used ARVs and concomitant medications between six different online drug–drug interaction databases. COMMENT: This was a cross‐sectional review using each of the following six databases: LexiComp®, Clinical Pharmacology®, Micromedex®, Epocrates®, University of Liverpool, and University of Toronto. Sixteen antiretroviral drugs and 100 of the DrugStats Database “Top 200 of 2019” list of medications were included. Each of the six databases identified a different number of actual or potential interactions. The number of interactions ranged from 211 to 283. WHAT IS NEW AND CONCLUSIONS: A variety of databases exist with inconsistent identification of actual or potential drug–drug interactions amongst them. It may be beneficial to cross‐reference multiple databases prior to making decisions regarding patient care. John Wiley and Sons Inc. 2022-09-04 2022-10 /pmc/articles/PMC9826109/ /pubmed/36059105 http://dx.doi.org/10.1111/jcpt.13750 Text en © 2022 The Authors. Journal of Clinical Pharmacy and Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Commentary Drwiega, Emily N. Badowski, Melissa E. Michienzi, Sarah Antiretroviral drug–drug interactions: A comparison of online drug interaction databases |
title | Antiretroviral drug–drug interactions: A comparison of online drug interaction databases |
title_full | Antiretroviral drug–drug interactions: A comparison of online drug interaction databases |
title_fullStr | Antiretroviral drug–drug interactions: A comparison of online drug interaction databases |
title_full_unstemmed | Antiretroviral drug–drug interactions: A comparison of online drug interaction databases |
title_short | Antiretroviral drug–drug interactions: A comparison of online drug interaction databases |
title_sort | antiretroviral drug–drug interactions: a comparison of online drug interaction databases |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826109/ https://www.ncbi.nlm.nih.gov/pubmed/36059105 http://dx.doi.org/10.1111/jcpt.13750 |
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